◀ Back to CTNNB1
CTNNB1 — ERBB2
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
Complex of CTNNB1-ERBB2
→
ERBB2
(directlyIncreases, CTNNB1/ERBB2 Activity)
Evidence: To investigate the potential interaction of Tiam1, HER2, and beta -catenin, cell lysates were immunoprecipitated with an anti-HER2 antibody, and the precipitated material was immunoblotted with different antibodies. We found no evidence of an association of Tiam1 with HER2 receptors (Fig. 2B). In contrast, there was a significant increase in the content of beta -catenin associated with activated HER2 receptor (Fig. 2B).
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BioCarta trefoil factors initiate mucosal healing:
TFFs/ErbB1/ERBB2 complex (EGFR-ERBB2-TFF3_TFF2_TFF1)
→
beta-catenin (CTNNB1)
(modification, activates)
-
KEGG Adherens junction:
EGFR/ERBB2
→
CTNNB1
(protein-protein, inhibition)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
CTNNB1
—
ERBB2
(physical association, affinity chromatography technology)
Bonvini et al., Cancer Res 2001*
-
IRef Biogrid Interaction:
CTNNB1
—
ERBB2
(physical association, affinity chromatography technology)
Schroeder et al., J Biol Chem 2002*
-
IRef Biogrid Interaction:
CTNNB1
—
ERBB2
(colocalization, imaging technique)
Schroeder et al., J Biol Chem 2002*
-
IRef Biogrid Interaction:
CTNNB1
—
ERBB2
(direct interaction, far western blotting)
Kanai et al., Biochem Biophys Res Commun 1995*
-
IRef Biogrid Interaction:
CTNNB1
—
ERBB2
(direct interaction, pull down)
Kanai et al., Biochem Biophys Res Commun 1995*
-
IRef Hprd Interaction:
CTNNB1
—
ERBB2
(in vitro)
Bonvini et al., Cancer Res 2001*, Kanai et al., Biochem Biophys Res Commun 1995*
-
IRef Hprd Interaction:
CTNNB1
—
ERBB2
(in vivo)
Bonvini et al., Cancer Res 2001*, Kanai et al., Biochem Biophys Res Commun 1995*
-
IRef Innatedb Interaction:
ERBB2
—
CTNNB1
(unknown, -)
Bonvini et al., Cancer Res 2001*
-
IRef Innatedb Interaction:
ERBB2
—
CTNNB1
(unknown, -)
Ochiai et al., Biochem Biophys Res Commun 1994*
-
IRef Intact Interaction:
Complex of 59 proteins
(association, tandem affinity purification)
Li et al., Molecular systems biology 2013
-
IRef Ophid Interaction:
ERBB2
—
CTNNB1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Bourguignon et al., J Biol Chem 2007
(Ovarian Neoplasms) :
Because HA-induced
beta-catenin phosphorylation, nuclear translocation, and TCF/LEF transcriptional activation is effectively
blocked by the
ErbB2 inhibitor, AG825, we conclude that HA/CD44-N-WASP associated ErbB2 activation is required for beta-catenin mediated signaling events
Liu et al., Int J Cancer 2009
(Carcinoma, Hepatocellular...) :
Given that HBxAg constitutively activates beta-catenin and that upregulated
ErbB-2 promotes
beta-catenin signaling in other tumor types, experiments were designed to ask whether HBxAg was associated with upregulated expression of ErbB-2 ... Treatment of HepG2X cells with ErbB-2 specific siRNA not only reduced ErbB-2 expression, but also reduced the expression of beta-catenin, suggesting that
ErbB-2 contributed to the stabilization of
beta-catenin