UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to UBE2D1

EP300 — UBE2D1

Pathways - manually collected, often from reviews:

NCI Pathway Database p53 pathway: p53 (TP53) → MDM2/UBCH5/Cbp/p300 complex (MDM2-UBE2D1-EP300_CREBBP) (proteasomal ubiquitin-dependent protein catabolic process, collaborate)
Rodriguez et al., Mol Cell Biol 2000, Mayo et al., Proc Natl Acad Sci U S A 2001, Zhou et al., Nat Cell Biol 2001, Li et al., Science 2003, Ferreon et al., Proc Natl Acad Sci U S A 2009, Siepe et al., Nat Cell Biol 2009, Haupt et al., Nature 1997
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database p53 pathway: p53/PIN1 complex (TP53-PIN1) → MDM2/UBCH5/Cbp/p300 complex (MDM2-UBE2D1-EP300_CREBBP) (proteasomal ubiquitin-dependent protein catabolic process, inhibits)
Rodriguez et al., Mol Cell Biol 2000, Mayo et al., Proc Natl Acad Sci U S A 2001, Zhou et al., Nat Cell Biol 2001, Li et al., Science 2003, Ferreon et al., Proc Natl Acad Sci U S A 2009, Siepe et al., Nat Cell Biol 2009, Haupt et al., Nature 1997
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database p53 pathway: nucleus (EP300/CREBBP) → MDM2/UBCH5 complex (MDM2-UBE2D1) (modification, collaborate)
Zhou et al., Nat Cell Biol 2001
Evidence: mutant phenotype, physical interaction
NCI Pathway Database p53 pathway: nucleus (EP300/CREBBP) → MDM2/UBCH5/Cbp/p300 complex (MDM2-UBE2D1-EP300_CREBBP) (modification, collaborate)
Zhou et al., Nat Cell Biol 2001
Evidence: mutant phenotype, physical interaction
NCI Pathway Database p53 pathway: MDM2/UBCH5 complex (MDM2-UBE2D1) → MDM2/UBCH5/Cbp/p300 complex (MDM2-UBE2D1-EP300_CREBBP) (modification, collaborate)
Zhou et al., Nat Cell Biol 2001
Evidence: mutant phenotype, physical interaction