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TIFA — TRAF6

Pathways - manually collected, often from reviews:

• WikiPathways Interleukin-1 Induced Activation of NF-kappa-B: Complex of AJUBA-PRKCZ-TIFA-SQSTM1-UBE2N-UBE2V1-TRAF6-IRAK1 → NFKB1 (activation)
• WikiPathways Interleukin-1 Induced Activation of NF-kappa-B: Complex of TRAF6-UBE2V1-TIFA-UBE2N-IRAK1 → Complex of AJUBA-PRKCZ-TIFA-SQSTM1-UBE2N-UBE2V1-TRAF6-IRAK1 (activation)
  
• WikiPathways Interleukin-1 Induced Activation of NF-kappa-B: IL1A → Complex of TRAF6-UBE2V1-TIFA-UBE2N-IRAK1 (activation)
  
• WikiPathways Regulation of toll-like receptor signaling pathway: TIFA → TRAF6 (unknown)
• WikiPathways Simplified Depiction of MYD88 Distinct Input-Output Pathway: TLR1/TLR2/TLR4/TLR5/TLR6/TLR7/TLR8/TLR9/TLR10/IL1A → Complex of UBE2N-UBE2V1-TRAF6-TIFA-IRAK1 (activation)
  
• WikiPathways Simplified Depiction of MYD88 Distinct Input-Output Pathway: Complex of TRAF6-TIFA-IRAK1-UBE2N-UBE2V1 → NFKB1 (activation)
• WikiPathways Simplified Depiction of MYD88 Distinct Input-Output Pathway: Complex of UBE2N-UBE2V1-TRAF6-TIFA-IRAK1 → Complex of TRAF6-TIFA-IRAK1-UBE2N-UBE2V1 (activation)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: TRAF6 — TIFA (physical association, affinity chromatography technology) Takatsuna et al., J Biol Chem 2003*
• IRef Hprd Interaction: TRAF6 — TIFA (in vitro) Takatsuna et al., J Biol Chem 2003*
• IRef Hprd Interaction: TRAF6 — TIFA (in vivo) Takatsuna et al., J Biol Chem 2003*

Text-mined interactions from Literome

Matsumura et al., Biochem Biophys Res Commun 2004 : These findings suggest that TIFAB inhibits the TIFA mediated TRAF6 activation possibly by inducing a conformational change in TIFA
Ea et al., Proc Natl Acad Sci U S A 2004 : Importantly, TIFA induces the oligomerization and polyubiquitination of TRAF6 , which leads to the activation of TAK1 and IKK through a proteasome independent mechanism