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FGF9 — SOX2
Text-mined interactions from Literome
Que et al., Development 2007
(Esophageal Atresia...) :
Organ culture experiments further suggest that
FGF signaling from the ventral mesenchyme
regulates Sox2 expression in the endoderm
Moniot et al., Development 2009
:
In the mouse XY gonad,
SOX9 upregulates
Fgf9 , which initiates a Sox9/Fgf9 feedforward loop, and Sox9 expression is stimulated by the prostaglandin D2 (PGD2) producing lipocalin prostaglandin D synthase ( L-PGDS, or PTDGS ) enzyme, which accelerates commitment to the male pathway