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AKAP5 — PRKAR2A
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
PRKAR2A
—
AKAP5
(direct interaction, unspecified method)
Alto et al., Proc Natl Acad Sci U S A 2003*
-
MIPS CORUM beta(1)-AR receptosome (ADRB1-SAP97-AKAP79-PRKAR2A):
beta(1)-AR receptosome (ADRB1-SAP97-AKAP79-PRKAR2A) complex (ADRB1-AKAP5-DLG1-PRKAR2A)
Gardner et al., J Biol Chem 2007*
-
MIPS CORUM Kinase-scaffold-phosphatase complex, PKA-AKAP79-CaN:
Kinase-scaffold-phosphatase complex, PKA-AKAP79-CaN complex (AKAP5-PPP3CA-PRKAR2A)
Oliveria et al., J Cell Biol 2003*
-
IRef Corum Interaction:
Complex of ADRB1-ADRB1-PRKAR2A-PRKAR2A-AKAP5-AKAP5-DLG1-DLG1
(association, fluorescent resonance energy transfer)
Gardner et al., J Biol Chem 2007*
-
IRef Corum Interaction:
Complex of PRKAR2A-AKAP5-PPP3CA
(association, fluorescent resonance energy transfer)
Oliveria et al., J Cell Biol 2003*
-
IRef Dip Interaction:
PRKAR2A
—
AKAP5
(physical association, biophysical)
Carr et al., J Biol Chem 1991*
-
IRef Intact Interaction:
Complex of 27 proteins
(association, tandem affinity purification)
Varjosalo et al., Nat Methods 2013
-
IRef Intact Interaction:
Complex of 23 proteins
(association, tandem affinity purification)
Varjosalo et al., Nat Methods 2013
-
IRef Intact Interaction:
PRKAR2A
—
AKAP5
(physical association, filter binding)
Willoughby et al., EMBO J 2006
-
IRef Ophid Interaction:
PRKAR2A
—
AKAP5
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
IRef Ophid Interaction:
PRKAR2A
—
AKAP5
(aggregation, confirmational text mining)
Alto et al., Proc Natl Acad Sci U S A 2003*
Text-mined interactions from Literome
Carr et al., Biochem J 1999
:
These results suggest that altered
PKA-AKAP interactions may contribute to the distinct responses of PA and PO follicles to high levels of cAMP, and that higher cAMP levels are
required to activate
PKA in PO ovaries
Sun et al., J Biol Chem 2000
:
Phosphorylation reactions mediated by CFTR associated PKA II are inhibited by Ht31 peptide but not by the control peptide Ht31P, indicating that a protein kinase A anchoring protein (
AKAP ) is
responsible for the association between
PKA and CFTR
Zakhary et al., J Biol Chem 2000
:
PKA stimulation of intact Chinese hamster ovary cells
increased RIIalpha binding to AKAP100/mAKAP and
AKAP15/18 by approximately 7- and 82-fold, respectively
Cong et al., J Biol Chem 2001
:
Mutants of
AKAP79 that do not bind PKA or target to the beta2AR markedly
inhibit phosphorylation of
beta2AR/PKA-
Niu et al., Curr Biol 2001
:
Finally,
AKAP110 significantly
potentiated G alpha 13-induced activation of
PKA
Brown et al., Biol Reprod 2002
:
By compartmentalizing PKA,
AKAP140 and/or other AKAPs could spatially
regulate PKA activity during oocyte development
Affaitati et al., J Biol Chem 2003
:
Here we show that conditional expression of
AKAP121 in PC12 cells selectively
enhances cAMP.PKA signaling to mitochondria
Chen et al., Eur J Cell Biol 2006
:
We have found that the functional regulation of the I ( Ks ) channel by
PKA requires the
A kinase anchoring protein ( AKAP ) Yotiao
Gardner et al., J Biol Chem 2007
:
Thus, the PDZ and its associated
SAP97-AKAP79 complex are
involved in targeting the cyclic AMP dependent
protein kinase (PKA) to the beta ( 1 ) -AR
Jeske et al., Pain 2009
(Calcium Signaling) :
Recent studies have reported that the A-kinase Anchoring Protein 150 (
AKAP150 )
mediates PKA phosphorylation of TRPV1 in several nociceptive models
Christian et al., J Biol Chem 2011
(Chronic Disease...) :
Small molecule
AKAP-protein kinase A (PKA) interaction disruptors that
activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes
Koçer et al., Journal of molecular signaling 2012
:
Using an AKAR2-AKAP5 fusion `` biosensor '', we investigated the spatial-temporal
activation of
AKAP5 undergoing phosphorylation by
PKA in response to ß-adrenergic stimulation
Sekiguchi et al., Br J Pharmacol 2013
(Hyperalgesia) :
In NG108-15 cells and/or rat DRG neurons, dibutyryl cAMP ( db-cAMP ) or PGE ( 2 ) increased T currents, an effect blocked by
AKAP St-Ht31 inhibitor peptide ( AKAPI ) or KT5720, a
PKA inhibitor
Dacher et al., J Neurosci 2013
:
Using immunofluorescence and whole-cell patch-clamp recording in rat midbrain slices, we show that activation of postsynaptic D ( 2 ) -like family of dopamine ( DA ) receptor in the ventral tegmental area ( VTA ) induces long-term depression ( LTD ) of GABAergic synapses on DA neurons through an inositol triphosphate receptor mediated local rise in postsynaptic Ca ( 2+ ) and CaN activation accompanied by
PKA inhibition, which
requires AKAP150 as a bridging signaling molecule