Gene interactions and pathways from curated databases and text-mining

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NR4A1 — TNF

Text-mined interactions from Literome

Gruber et al., Blood 2003 (Arteriosclerosis) : Nur77 , itself, is transcriptionally up-regulated by TNFalpha
Suzuki et al., Proc Natl Acad Sci U S A 2003 : Nur77 expression is strongly induced by TNF
Darragh et al., Biochem J 2005 (MAP Kinase Signaling System) : The induction of Nur77 by TNF and anisomycin was abolished in MSK1/2 double-knockout cells, whereas induction was significantly reduced in response to PMA or EGF ... Consistent with the decrease in Nur77 mRNA levels in the MSK1/2-knockout cells, it was also found that MSKs were required for the induction of Nur77 protein by PMA and TNF
Liu et al., Biochem Biophys Res Commun 2005 : RG and PG attenuated TNFalpha mediated induction of trans acting factor ( s ) Nur77/Nurr1 and binding of nuclear proteins ( NP ) to the cis acting element ( NBRE )