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MEFV — NR4A1
Text-mined interactions from Literome
Youn et al., Science 1999
(Calcium Signaling) :
Nur77 expression is
controlled by the transcription factor
myocyte enhancer factor 2 (MEF2) , but how MEF2 is activated by calcium signaling is still obscure
Youn et al., Immunity 2000
(Calcium Signaling) :
Cabin1 represses
MEF2 dependent
Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2 ... Thus, activation of MEF2 and the consequent transcription of
Nur77 are
controlled by the association of
MEF2 with the histone deacetylases via the calcium dependent repressor Cabin1
Liu et al., Eur J Immunol 2001
:
Thapsigargin induced apoptosis involves
Cabin1-MEF2 mediated
induction of
Nur77 ... The TG-induced Nur77 expression is also inhibited by overexpression of Cabin1, an endogenous inhibitor of calcineurin and a corepressor of the transcription factor MEF2, suggesting that
MEF2 activation is
required for
Nur77 expression
Esau et al., J Exp Med 2001
:
In cell lines, these interactions were shown to inhibit calcineurin activity after T cell receptor ( TCR ) signaling and transcriptional
activation of
Nur77 by
MEF2