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IRF7 — NFKB1
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Zhang et al., J Virol 2001
:
In addition,
NF-kappaB is
involved in the induction of
IRF-7 ... A superrepressor of IkappaB ( sr-IkappaB ) could block the induction of
IRF-7 by LMP-1, and overexpression of
NF-kappaB ( p65 plus p50 ) could
induce the expression of IRF-7
Dai et al., J Immunol 2004
:
In this study, we demonstrate that both LPS and HSV up-regulate the expression of IRF-7 in PDC, and that this enhancement of
IRF-7 is
dependent on
NF-kappa B activation
Song et al., Proc Natl Acad Sci U S A 2008
:
Association with active LMP1 signaling complexes was also critical for IRF7 activation because (i) a dominant negative IRF7 bound to LMP1, blocked IRF7 association and activation, but did not
inhibit LMP1 induced
NF-kappaB or TBK1 or Sendai virus mediated IFN stimulated response element activation ; and ( ii ) two different LMP1 transmembrane domain mutants, which fail to aggregate, each bound
IRF7 and prevented LMP1 from binding and activating IRF7 in the same cell, but did not prevent NF-kappaB activation
Cheng et al., J Interferon Cytokine Res 1998
:
Therefore, effective ISRE activity of IP-10 VRE may require an
IRF-like protein binding, which is
enhanced by an
NF-kappaB heterodimer binding to an adjacent KB site