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CARD9 — NFKB1
Pathways - manually collected, often from reviews:
-
KEGG Tuberculosis:
Complex of BCL10-CARD9-MALT1
→
NFKB1/RELA
(protein-protein, activation)
Text-mined interactions from Literome
Koseki et al., J Biol Chem 1999
:
Point mutations in highly conserved residues in the CARD of CIPER disrupted the ability of CIPER to activate NF-kappaB and to form homodimers, indicating that the
CARD is
essential for
NF-kappaB activation and dimerization
Bertin et al., J Biol Chem 2000
:
CARD9 is a novel caspase recruitment domain containing protein that interacts with BCL10/CLAP and
activates NF-kappa B ... When expressed in cells,
CARD9 binds to BCL10 and
activates NF-kappaB ... When expressed in cells,
CARD9 binds to BCL10 and
activates NF-kappaB ... We propose here that
CARD9 is an upstream
activator of BCL10 and
NF-kappaB signaling
Bertin et al., J Biol Chem 2001
:
When expressed in cells,
CARD11 and CARD14
activate NF-kappaB and induce the phosphorylation of BCL10
Gross et al., Nature 2006
:
Card9 couples to Bcl10 and
regulates Bcl10-Malt1 mediated
NF-kappaB activation induced by zymosan
Fontalba et al., J Immunol 2007
(Arthritis, Rheumatoid) :
Thus,
CARD8 may
control NF-kappaB activation through a regulatory loop
Hara et al., J Immunol 2008
:
Cell type-specific regulation of ITAM mediated
NF-kappaB activation by the adaptors, CARMA1 and
CARD9 ... Although the
caspase recruitment domain (CARD)9-Bcl10 complex is
essential for FcRgamma/DAP12 mediated
NF-kappaB activation in myeloid cells, its involvement in NK cell receptor signaling is unknown
Goodridge et al., J Immunol 2009
:
A recent report identified a role for CARD9 in innate anti-fungal responses, demonstrating
CARD9-Bcl10 mediated activation of
NF-kappaB and proinflammatory cytokine induction in murine bone marrow derived DC stimulated via Dectin-1
Bi et al., J Biol Chem 2010
:
However, the molecular mechanism by which
CARD9 mediates C. albicans induced
NF-kappaB activation is not fully characterized ... Here we demonstrate that
CARD9 is
involved in mediating
NF-kappaB activation induced by the hyphal form of C. albicans hyphae ( Hyphae ) but not by its heat inactivated unicellular form ... Finally, we find that although both
CARD9 and Syk are
required for Hyphae induced
NF-kappaB activation, they regulate different signaling events in which CARD9 mediates IkappaBalpha kinase ubiquitination, whereas Syk regulates IkappaBalpha kinase phosphorylation ... Together, our data demonstrated that
CARD9 is selectively
involved in Dectin-2 induced
NF-kappaB activation in response to C. albicans hyphae challenging