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HES1 — NEUROD4

Text-mined interactions from Literome

Takatsuka et al., Brain Res 2004 : Previously, we demonstrated that the bHLH gene Hes1 inhibits neuronal differentiation whereas, in Hes1-null retina, precursors prematurely differentiate into neurons and form abnormal rosette-like structures
Bai et al., Dev Cell 2007 : Overexpression of Id2 in the chick hindbrain upregulates Hes1 expression and inhibits proneural gene expression and neuronal differentiation
Zhang et al., Brain Res 2010 : Our results demonstrated that Mash1, Id2, Hes1 were all widely expressed in in vitro progenies from mouse SVZa NPCs. Analyses of SVZa NPCs transfected with eukaryotic expression plasmids showed that Mash1 promoted neuronal differentiation from SVZa NPCs, while Id2 and Hes1 repressed neuronal differentiation
Wang et al., Front Biosci (Elite Ed) 2010 : Thus, our results indicate that miR-124 regulates the expression of Hes-1 at the post-transcriptional level and is involved in the retinoic acid induced neuronal differentiation of P19 cells
Tan et al., Genes Cells 2012 : Over-expression of miR-9 negatively regulates the Hes1 protein expression by interacting with the 3'-UTR of Hes1 mRNA, thereby inducing cell cycle exit and neuronal differentiation
Katakura et al., Stem cells international 2013 : In the present study, we examined the effect of eicosapentaenoic acid ( EPA ) and arachidonic acid ( AA ) on differentiation, expression of basic helix-loop-helix transcription factors ( Hes1, Hes6, and NeuroD ), and the cell cycle of cultured NSCs. EPA also increased mRNA levels of Hes1 , an inhibitor of neuronal differentiation , Hes6, an inhibitor of Hes1, NeuroD, and Map2 mRNA and Tuj-1 positive cells ( a neuronal marker ), indicating that EPA induced neuronal differentiation
Kageyama et al., Int J Biochem Cell Biol 1997 : Thus, HES1 regulates brain and eye morphogenesis by inhibiting premature neuronal differentiation , and the down-regulation of HES1 expression at the right time is required for normal development of the nervous system ... Thus, HES1 regulates brain and eye morphogenesis by inhibiting premature neuronal differentiation , and the down-regulation of HES1 expression at the right time is required for normal development of the nervous system
Ohtsuka et al., Cell Tissue Res 1998 : The expression of HES-1 , a negative regulator of the neuronal differentiation , was upregulated temporarily in accordance with the suppression of the v-myc expression and was downregulated upon the differentiation of HC2S2 cells into neurons