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EXO1 — MSH2

Pathways - manually collected, often from reviews:

• Reactome Reaction: MSH2 → EXO1 (indirect_complex) Nielsen et al., Oncogene 2004, Zhang et al., Cell 2005, Constantin et al., J Biol Chem 2005, Knudsen et al., Nucleic Acids Res 2007, Liberti et al., DNA repair 2011
• Reactome Reaction: MSH2 → EXO1 (reaction) Nielsen et al., Oncogene 2004, Zhang et al., Cell 2005, Constantin et al., J Biol Chem 2005, Knudsen et al., Nucleic Acids Res 2007, Liberti et al., DNA repair 2011

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: MSH2 — EXO1 Rasmussen et al., Mutat Res 2000*, Jäger et al., Oncogene 2001*
• IRef Bind_translation Interaction: MSH2 — EXO1 (affinity chromatography technology) Jäger et al., Oncogene 2001*
• IRef Bind_translation Interaction: MSH2 — EXO1 (two hybrid) Jäger et al., Oncogene 2001*
• IRef Biogrid Interaction: MSH2 — EXO1 (direct interaction, two hybrid) Rasmussen et al., Mutat Res 2000*
• IRef Biogrid Interaction: MSH2 — EXO1 (direct interaction, pull down) Schmutte et al., Cancer Res 1998*
• IRef Biogrid Interaction: MSH2 — EXO1 (direct interaction, pull down) Schmutte et al., J Biol Chem 2001*
• IRef Biogrid Interaction: MSH2 — EXO1 (direct interaction, pull down) Dherin et al., Mol Cell Biol 2009*
• IRef Biogrid Interaction: MSH2 — EXO1 (direct interaction, pull down) Andersen et al., DNA repair 2012
• IRef Hprd Interaction: MSH2 — EXO1 (in vitro) Rasmussen et al., Mutat Res 2000*, Jäger et al., Oncogene 2001*, Nielsen et al., Oncogene 2004, Dherin et al., Mol Cell Biol 2009*, Schmutte et al., Cancer Res 1998*
• IRef Hprd Interaction: MSH2 — EXO1 (two hybrid) Rasmussen et al., Mutat Res 2000*, Jäger et al., Oncogene 2001*, Nielsen et al., Oncogene 2004, Dherin et al., Mol Cell Biol 2009*, Schmutte et al., Cancer Res 1998*
• IRef Hprd Interaction: MSH2 — EXO1 (in vivo) Rasmussen et al., Mutat Res 2000*, Jäger et al., Oncogene 2001*, Nielsen et al., Oncogene 2004, Dherin et al., Mol Cell Biol 2009*, Schmutte et al., Cancer Res 1998*
• IRef Intact Interaction: MSH2 — EXO1 (physical association, two hybrid) Rasmussen et al., Mutat Res 2000*
• IRef Ophid Interaction: MSH2 — EXO1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Doherty et al., J Biol Chem 2005 : Importantly, RECQ1 stimulates the incision activity of human exonuclease 1 and the mismatch repair recognition complex MSH2/6 stimulates RECQ1 helicase activity
McDowell et al., Environ Mol Mutagen 2008 : Our results demonstrated that hEXO1 is capable of degrading duplex DNA containing an O6-methylguanine ( O6-meG ) adduct paired with either a C or a T. Additionally, the hMSH2-hMSH6 complex stimulated hEXO1 exonuclease activity on the O6-meG/T and O6-meG/C DNA substrates