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GAS6 — MAPK3
Text-mined interactions from Literome
Goruppi et al., Oncogene 1999
:
We further show evidence that
Gas6 stimulation of serum starved NIH3T3 cells
results in a transient ERK, JNK/SAPK and p38
MAPK activation
Katagiri et al., J Biol Chem 2001
(Bone Resorption) :
Gas6 up-regulated the phosphorylation of cellular proteins including p42/p44 mitogen activated protein kinase ( MAPK ), but not p38 or c-Jun N-terminal kinase
MAPK , and increased the kinase activity of immunoprecipitated Tyro 3 in isolated osteoclasts ... These results strongly suggest that
Gas6 acts directly on mature osteoclasts through activation of Tyro 3 and p42/p44
MAPK , possibly contributing to the bone loss by estrogen deficiency ... These results strongly suggest that
Gas6 acts directly on mature osteoclasts through activation of Tyro 3 and
p42/p44 MAPK , possibly contributing to the bone loss by estrogen deficiency
Motomura et al., Biochem Biophys Res Commun 2007
:
Gas6 signaling
activated the phosphorylation of ERK1/2, SAPK/JNK, and Akt, but not p38
MAPK
Lee et al., Biochem Biophys Res Commun 2013
(MAP Kinase Signaling System...) :
Gas6 induces cancer cell migration and epithelial-mesenchymal transition through upregulation of
MAPK and Slug