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EIF4E — MAPK3
Text-mined interactions from Literome
Takei et al., J Biol Chem 2001
(MAP Kinase Signaling System) :
In contrast, insulin failed to activate
MAPK and did not
induce the phosphorylation of
eIF4E
Banerjee et al., J Virol 2002
:
Interestingly, there was a transient increase in the amount of phosphorylation of the translation initiation factor 4E ( eIF4E ) in infected cells, and this
eIF4E phosphorylation was p38
MAPK dependent ; it is known that phosphorylated eIF4E enhances translation rates of cap containing mRNAs ... MHV utilized this p38
MAPK dependent increase in
eIF4E phosphorylation to promote virus-specific protein synthesis and subsequent progeny virus production
Mizutani et al., Biochem Biophys Res Commun 2004
(MAP Kinase Signaling System...) :
The p38
MAPK inhibitor, SB203580,
inhibited effectively phosphorylation of HSP-27, CREB, and
eIF4E in SARS-CoV infected cells
Cowan et al., Eur J Biochem 2004
:
Prolonged incubation with MG132 resulted in the increased expression of heat shock protein ( hsp ) 25, alphaB-crystallin and hsp70, with a population of hsp25 associating with the
eIF4F complex in a p38
mitogen activated protein kinase dependent manner
Ramesh et al., American journal of physiology. Renal physiology 2007
:
Inhibition of p38
MAPK and, to a lesser extent, ERK,
reduced cisplatin+endotoxin stimulated TNF-alpha production and phosphorylation of Mnk1 and
eIF4E
Jiang et al., Planta Med 2007
(Stomach Neoplasms) :
We found that matrine inactivated
Erk1/2 , an upstream
regulator of 4E-BP1 and
eIF4E , and remarkably reduced the phosphorylation level of 4E-BP1 and eIF4E, whereas 4E-BP1 was little influenced by JNK, p38 or Akt/mTOR
Das et al., J Cell Physiol 2013
(MAP Kinase Signaling System) :
Inhibition of
Erk1/2 by MEK inhibitor or by expression of dominant negative Erk2
blocked eIF4E phosphorylation, resulting in attenuation of TGFß induced protein synthesis and mesangial cell hypertrophy
Jiang et al., FEBS Lett 2013
:
MKK3/6 dependent activation of
p38MAPK is
required for the phosphorylation of
eIF4E , thus initiating the translation of ER stress related transcription factor ATF4
Morley et al., J Biol Chem 1997
:
However, the rapid enhancement of
eIF4E phosphorylation in response to serum was largely
prevented by the inhibitor of
mitogen activated protein ( MAP ) kinase activation, PD98059