Gene interactions and pathways from curated databases and text-mining

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IFNG — IRS1

Text-mined interactions from Literome

Argetsinger et al., J Biol Chem 1995 : Growth hormone, interferon-gamma , and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1 ... The correlation between JAK2 tyrosyl phosphorylation and IRS-1 tyrosyl phosphorylation in response to GH, interferon-gamma , and leukemia inhibitory factor and in cells expressing different GHR mutants, provides evidence that IRS-1 may interact with JAK2 or an auxiliary molecule that binds to JAK2
Huppertz et al., Diabetologia 1996 : The effects of insulin, insulin-like growth factor (IGF)-I, platelet derived growth factor ( PDGF ), interleukin (IL)-6 and interferon-gamma on 2-deoxyglucose uptake and insulin receptor substrate (IRS)-1 phosphorylation were compared in 3T3-L1 cells at confluence and after differentiation to the adipocyte-like phenotype
Burfoot et al., J Biol Chem 1997 : Neither IRS-1 nor IRS-2 was detectably activated by IFN-gamma