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IL2 — SHB

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: SHB → IL2 (increases) Annerén et al., Curr Mol Med 2003*
  Evidence: Full text: PDGF, FGF-2, NGF, CD3-stimulation (T cell receptor ligation), endostatin and Interleukin-2 all cause tyrosine phosphorylation of SHB if added to the appropriate target cells [12, 14, 16, 18-20].

Text-mined interactions from Literome

Lindholm et al., Biochem Biophys Res Commun 2002 : This study addresses a role of the Shb adapter protein in IL-2 receptor signaling in T and NK cells
Annerén et al., Curr Mol Med 2003 : In Jurkat T cells, SHB links several signaling components with the TCR and is thus required for IL-2 production