Mezger et al., J Infect Dis 2008
(Aspergillosis) :
Silencing of dectin-1 resulted in reduced expression of proinflammatory cytokines ( tumor necrosis factor-alpha and interleukin-12 ), which was also reduced by anti-Dectin-1 antibody treatment prior to exposure to A. fumigatus, zymosan, or Candida albicans
Tassi et al., Eur J Immunol 2009
:
Moreover, PLCgamma2 controlled Dectin-1 mediated NFAT activation and induction of NFAT dependent genes such as IL-2 , cyclooxigenase-2 and Egr transcription factors