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IL18 — SPP1
Text-mined interactions from Literome
Koguchi et al., Infect Immun 2002
(AIDS-Related Opportunistic Infections) :
Penicillium marneffei causes
osteopontin mediated production of
interleukin-12 by peripheral blood mononuclear cells
Himeno et al., J Bone Miner Res 2002
(Ossification, Heterotopic) :
In primary culture of Cbfa1-/- chondrocytes, transforming growth factor (TGF) beta1, platelet derived growth factor ( PDGF ),
interleukin (IL)-1beta , and thyroid hormone ( T3 )
induced osteopontin and MMP-13 expression
Mas et al., Mult Scler 2007
(Genetic Predisposition to Disease...) :
OPN enhances the production of the pro-inflammatory cytokines,
interleukin-12 and interferon-gamma, while reducing interleukin-10 levels
Diao et al., Cytokine 2012
(Drug-Induced Liver Injury...) :
Osteopontin regulates
interleukin-17 production in hepatitis
Ahmad et al., PloS one 2013
(Insulin Resistance...) :
Interestingly,
OPN levels
increased progressively with an increase in
IL-18 levels ( r?=?0.52, P?=?0.0004 ) ... We also examined the regulatory
role of
IL-18 in
OPN secretion from PBMCs. Neutralizing anti-IL-18Ra mAb reduced OPN secretion ... Moreover, these results provide the direct evidence that
IL-18 regulates
OPN production in PBMCs
Singh et al., J Biol Chem 1995
:
In vitro,
interleukin-1 beta and interferon-gamma
increased osteopontin mRNA levels in CMEC as well as NOS2 expression in both CMEC and cardiac myocytes