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CXCL16 — IL18

Text-mined interactions from Literome

Chandrasekar et al., J Biol Chem 2005 : The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88, interleukin-1 receptor associated kinase, tumor necrosis factor receptor associated factor 6, c-Src, phosphatidylinositol 3-kinase, Akt, c-Jun N-terminal kinase, and activator protein-1 signaling ... Here we reort that interleukin (IL)-18 positively regulates CXCL16 transcription in rat ASMC ... Deletion or mutation of this site attenuated IL-18 mediated CXCL16 promoter activity ... Src kinase inhibitors PP1 and PP2, phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002, Akt inhibitor, the c-Jun N-terminal kinase (JNK) inhibitor SP600125, antisense JNK and dominant negative MyD88, interleukin-1 receptor associated kinase ( IRAK)-1, IRAK4, and phosphatidylinositol 3-kinase expression all attenuated IL-18 mediated AP-1 binding and reporter activity, CXCL16 promoter-reporter activity, and CXCL16 expression ... These data provide for the first time a mechanism of IL-18 mediated CXCL16 gene transcription and CXCL16 dependent ASMC proliferation and suggest a role for IL-18-CXCL16 cross-talk in atherogenesis and restenosis following angioplasty
Kanda et al., Eur J Immunol 2007 : IL-18 enhances IFN-gamma induced production of CXCL9, CXCL10 , and CXCL11 in human keratinocytes ... We examined the in vitro effects of IL-18 on IFN-gamma induced CXCL9, CXCL10 , and CXCL11 production in human keratinocytes ... IL-18 enhanced the IFN-gamma induced secretion and mRNA expression of CXCL9, CXCL10 , and CXCL11 in parallel to the activation of NF-kappaB, STAT1, and IFN-regulatory factor (IRF)-1