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IGF1 — SREBF1
Text-mined interactions from Literome
Smith et al., J Invest Dermatol 2008
(Acne Vulgaris...) :
IGF-1 induces
SREBP-1 expression and lipogenesis in SEB-1 sebocytes via activation of the phosphoinositide 3-kinase/Akt pathway ...
IGF-1 increases expression of sterol response element binding protein-1 (
SREBP-1 ), a transcription factor that regulates numerous genes involved in lipid biosynthesis ... Using specific inhibitors of each pathway, we found that the increase in expression of
SREBP-1 induced by
IGF-1 was blocked in the presence of the PI3-K inhibitor but not in the presence of the MAPK/ERK inhibitor
Streicher et al., J Biol Chem 1996
:
SREBP-1 mediates activation of the low density lipoprotein receptor promoter by insulin and
insulin-like growth factor-I