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IGF1 — MRXS5

Text-mined interactions from Literome

Linkhart et al., Endocrinology 1992 (Bone Resorption) : The results are consistent with the hypotheses that 1 ) IL-1 stimulates IGF-I production by bone cells, in part by PG-dependent mechanisms ; 2 ) the effects of IL-1 and PGs on bone formation and resorption may be mediated by locally induced secretion of IGF-I and other growth factors in bone
Mitropoulou et al., Biochimie 2004 (Breast Neoplasms) : IGF-I affects the synthesis of PGs by BT-20 cells by decreasing the amounts of HA and secreted GalAGPGs and HSPGs and upregulates the expression of cell membrane associated GalAGPGs and HSPGs. IGF-I exerts this effect on BT-20 cells acting mainly through receptors with protein tyrosine kinase activity ( PTK ) ... It is suggested that the effects of IGF-I on the synthesis and distribution of PGs by epithelial breast cancer cells also depend on the presence or the absence of ER
Watanabe et al., Kidney Int 1992 : These results indicate that IGF enhances the biosynthesis of PGs/GAGs by various cell types of the renal glomerulus, especially that of the mesangial cell, as reflected by the selective increase of chondroitin/dermatan sulfate
Gebrekristos et al., Growth Horm IGF Res 2010 (Ductus Arteriosus, Patent) : These results provide evidence for an involvement of PGs in the regulation of growth as well as the GH-IGF and HPA axes
Raisz et al., Endocrinology 1993 : In 96-h fetal rat calvarial organ cultures, PGE2 increased, and cortisol and indomethacin decreased the medium IGF-I concentration, suggesting that both exogenous and endogenous PGs regulate IGF-I production
Watanabe et al., Endocrinology 1994 : The analysis of IGF-IR by specific binding studies revealed a decreased concentration of the receptors, but an increased IGF-I binding affinity, the latter of which probably contributed to the IGF-I induced accentuated synthesis of renal glomerular PGs in the Hx group