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GJA1 — IGF1

Text-mined interactions from Literome

Lin et al., Invest Ophthalmol Vis Sci 2003 : IGF-I induced phosphorylation of connexin 43 by PKCgamma : regulation of gap junctions in rabbit lens epithelial cells ... To determine the role of PKCgamma in insulin-like growth factor (IGF)-I induced phosphorylation of connexin (Cx)43 and control of gap junctions in lens epithelial cells
Aberg et al., J Neurosci Res 2003 : Insulin-like growth factor-I increases astrocyte intercellular gap junctional communication and connexin43 expression in vitro
Lin et al., Invest Ophthalmol Vis Sci 2003 : Phorbol ester ( TPA ) and insulin-like growth factor (IGF)-1 recruited PKCgamma into Cav-1 containing lipid rafts and stimulated the interactions of PKCgamma with Cav-1 and Cx43 ... Activation of PKCgamma by TPA or IGF-1 stimulated the interaction of PKCgamma with Cav-1 and Cx43 in lipid rafts, causing Cx43, Cav-1, and PKCgamma to redistribute within the lipid rafts, and this resulted in a decrease in gap junction plaques
Nguyen et al., J Biol Chem 2004 : We have shown previously that insulin-like growth factor-I or lens epithelium derived growth factor increases the translocation of protein kinase Cgamma ( PKCgamma ) to the membrane and the phosphorylation of Cx43 by PKCgamma and causes a subsequent decrease of gap junction activity ( Nguyen, T. A., Boyle, D. L., Wagner, L. M., Shinohara, T., and Takemoto, D. J. ( 2003 ) Exp. Eye Res. 76, 565-572 ; Lin, D., Boyle, D. L., and Takemoto, D. J. ( 2003 ) Investig
Jia et al., J Surg Res 2007 : Angiotensin II and IGF-1 regulate connexin43 expression via ERK and p38 signaling pathways in vascular smooth muscle cells of coronary artery bypass conduits ... Using immunohistochemistry, Western blot, and reverse-transcription polymerase chain reaction, we assessed the effect of Ang II and IGF-1 stimulation on connexin43 expression and the signaling pathways involved in VSMCs of SV and IMA ... IGF-1 dose-dependently induced mRNA expression of connexin43 in the VSMCs of SV, which was blocked by PD98059 ... However, in VSMCs of IMA there was no significant effect of IGF-1 on the connexin43 mRNA expression
Jia et al., J Cell Mol Med 2011 : Cross-talk between angiotensin II and IGF-1 induced connexin 43 expression in human saphenous vein smooth muscle cells ... Moreover, AT-II and IGF-1 induced Cx43 expression via phosphorylation of Erk 1/2 and activation of transcription factor activator protein 1 (AP-1) through their reciprocal receptors in SV SMCs ... These data demonstrate a cross-talk between IGF-1R and AT-1R in AT-II and IGF-1 induced Cx43 expression in SV SMCs involving Erk 1/2 and downstream activation of the AP-1 transcription factor