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ANG — IGF1
Text-mined interactions from Literome
Brink et al., Hypertension 1999
(Hypertrophy, Left Ventricular) :
In conclusion, autocrine
upregulation of cardiac
IGF-I and IGF-IR mRNA by
Ang II occurs through hemodynamic and nonhemodynamic mechanisms, respectively, and may modulate cardiac structural changes that occur in hypertension
Serneri et al., Circ Res 2001
(Cardiomyopathy, Dilated...) :
This study demonstrates that ( 1 ) the clinical course of HF is associated with progressive increase in cardiac Ang II formation, ( 2 ) AT(1) density does not change on failing myocytes, and ( 3 ) failing myocytes are unable to synthesize
IGF-I and ET-1 in
response to
Ang II stimulation
Phelps et al., Am J Physiol Cell Physiol 2006
:
In contrast,
IGF-I , which did not significantly activate ERK or JNK,
stimulated increased
Ang2 expression through transcriptional activation