◀ Back to GNA11
GNA11 — PLCB3
Pathways - manually collected, often from reviews:
-
KEGG Vascular smooth muscle contraction:
GNA11/GNAQ
→
PLCB1/PLCB2/PLCB3/PLCB4
(protein-protein, activation)
-
KEGG Gap junction:
GNA11/GNAQ
→
PLCB1/PLCB2/PLCB3/PLCB4
(protein-protein, activation)
-
KEGG Cholinergic synapse:
GNA11/GNAQ
→
PLCB1/PLCB2/PLCB3/PLCB4
(protein-protein, activation)
-
KEGG Long-term depression:
GNA11/GNAQ
→
PLCB1/PLCB2/PLCB3/PLCB4
(protein-protein, activation)
-
KEGG Long-term depression:
GNA11/GNAQ
→
PLCB1/PLCB2/PLCB3/PLCB4
(protein-protein, activation)
-
KEGG GnRH signaling pathway:
GNA11/GNAQ
→
PLCB1/PLCB2/PLCB3/PLCB4
(protein-protein, activation)
-
KEGG Chagas disease (American trypanosomiasis):
GNA11/GNA14/GNA15/GNAQ
→
PLCB1/PLCB2/PLCB3/PLCB4
(protein-protein, activation)
-
KEGG Amoebiasis:
GNA11/GNA14/GNA15/GNAQ
→
PLCB1/PLCB2/PLCB3/PLCB4
(protein-protein, activation)
-
KEGG Calcium signaling pathway:
GNA11/GNA14/GNA15/GNAQ
→
PLCB1/PLCB2/PLCB3/PLCB4
(protein-protein, activation)
-
NCI Pathway Database Endothelins:
None
→
ETB receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1)
(modification, collaborate)
Aramori et al., J Biol Chem 1992, Takuwa et al., Am J Physiol 1989, Resink et al., Biochem Biophys Res Commun 1988
Evidence: assay, other species
-
NCI Pathway Database Endothelins:
ETB receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1)
(modification, activates)
Aramori et al., J Biol Chem 1992, Takuwa et al., Am J Physiol 1989, Resink et al., Biochem Biophys Res Commun 1988
Evidence: assay, other species
-
NCI Pathway Database Endothelins:
ETB receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1)
→
None
(modification, activates)
Aramori et al., J Biol Chem 1992, Takuwa et al., Am J Physiol 1989, Resink et al., Biochem Biophys Res Commun 1988
Evidence: assay, other species
-
NCI Pathway Database Plasma membrane estrogen receptor signaling:
Gq family/GTP complex (GNA11_GNAQ_GNA15_GNA14)
→
PLC beta (PLCB3/PLCB2/PLCB1)
(modification, activates)
Le Mellay et al., J Biol Chem 1997
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database Endothelins:
ETA receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRA-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1)
→
PLC beta (PLCB3/PLCB2/PLCB1)
(modification, collaborate)
Aramori et al., J Biol Chem 1992
-
NCI Pathway Database Endothelins:
ETA receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRA-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1)
→
ETA receptor/Endothelin-1/Gq/GTP complex (EDNRA-EDN1-GNA11_GNAQ_GNA15_GNA14)
(modification, collaborate)
Aramori et al., J Biol Chem 1992
-
NCI Pathway Database Endothelins:
PLC beta (PLCB3/PLCB2/PLCB1)
→
ETA receptor/Endothelin-1/Gq/GTP complex (EDNRA-EDN1-GNA11_GNAQ_GNA15_GNA14)
(modification, collaborate)
Aramori et al., J Biol Chem 1992
-
NCI Pathway Database PAR1-mediated thrombin signaling events:
Gq family/GTP complex (GNA11_GNAQ_GNA15_GNA14)
→
PLC beta (PLCB3/PLCB2/PLCB1)
(modification, activates)
Hung et al., J Biol Chem 1992
Evidence: genetic interaction, other species
-
NCI Pathway Database Endothelins:
None
→
ETA receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRA-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1)
(modification, collaborate)
Aramori et al., J Biol Chem 1992, Takuwa et al., Am J Physiol 1989, Resink et al., Biochem Biophys Res Commun 1988
Evidence: assay, other species
-
NCI Pathway Database Endothelins:
ETA receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRA-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1)
→
None
(modification, activates)
Aramori et al., J Biol Chem 1992, Takuwa et al., Am J Physiol 1989, Resink et al., Biochem Biophys Res Commun 1988
Evidence: assay, other species
-
NCI Pathway Database Endothelins:
ETB receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1)
→
p38 alpha (MAPK14)
(modification, activates)
Aquilla et al., J Biol Chem 1996
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endothelins:
ETB receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1)
→
PLC beta (PLCB3/PLCB2/PLCB1)
(modification, collaborate)
Aramori et al., J Biol Chem 1992
-
NCI Pathway Database Endothelins:
ETB receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1)
→
ETB receptor/Endothelin-1/Gq/GTP complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14)
(modification, collaborate)
Aramori et al., J Biol Chem 1992
-
NCI Pathway Database Endothelins:
PLC beta (PLCB3/PLCB2/PLCB1)
→
ETB receptor/Endothelin-1/Gq/GTP complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14)
(modification, collaborate)
Aramori et al., J Biol Chem 1992
-
Reactome Reaction:
GNA11
→
PLCB3
(indirect_complex)
Singer et al., Nat Struct Biol 2002, Hubbard et al., Cell Signal 2006
-
Reactome Reaction:
GNA11
→
PLCB3
(reaction)
Singer et al., Nat Struct Biol 2002, Hubbard et al., Cell Signal 2006
-
WikiPathways GPR40 Pathway:
GNA11
→
PLCG1/PLCG2/PLCE1/PLCB1/PLCB2/PLCD1/PLCZ1/PLCB3/PLCH1/PLCL1/PLCD3
(activation)
-
WikiPathways G Protein Signaling Pathways:
GNAQ/GNA11/GNA14/GNA15
→
PLCB3
(activation)
-
WikiPathways Calcium Regulation in the Cardiac Cell:
GNA11
→
PLCB3/PLCB3
(activation)
Text-mined interactions from Literome
Cunningham et al., Mol Pharmacol 1999
:
Protein kinase C-promoted inhibition of
Galpha(11) stimulated
phospholipase C-beta activity
Stanners et al., J Biol Chem 1995
:
Here, we report TCR.CD3 mediated guanine nucleotide exchange among the 42-kDa G protein alpha subunits of the G alpha q/11 family, their physical association with CD3 epsilon, and the
G alpha 11-dependent activation of
phospholipase C beta
Jiang et al., J Biol Chem 1996
:
PLC beta3 can be
activated by Galphaq,
Galpha11 , and Galpha16 in the cotransfection assay
Waldo et al., Biochem J 1996
:
Molecular cloning, expression and regulatory activity of
G alpha 11- and beta gamma-subunit
stimulated phospholipase C-beta from avian erythrocytes