Lee et al., Neuroreport 2004
:
Differential role of ERK in cAMP induced Nurr1 expression in N2A and C6 cells
Jacobsen et al., Neurobiol Dis 2008
(Neuroblastoma) :
These results indicate that Ser125 is critical for basal and ERK1/2 induced NURR1 activity and suggest a role for this and other NURR1 mutations in the regulation of dopamine synthesis and predisposition to Parkinson 's disease
Zhang et al., Journal of cell communication and signaling 2010
:
In addition, PKC or MEK1/2 inhibition prevented ERK1/2 phosphorylation and antagonized AR-mediated induction of NR4A2 and NR4A3, suggesting the involvement of these kinases in AR to NR4A signaling