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EPHB2 — MIF
Text-mined interactions from Literome
Nguyen et al., J Biol Chem 2003
(Inflammation) :
Cyclo-57,60- [ Asp57,Dap60 ]
MIF- ( 50-65 )
activated ERK1/2 , indicating that CXXC dependent disulfide and beta-turn formation is associated with an activity inducing conformation
Swant et al., J Biol Chem 2005
(Cell Transformation, Neoplastic...) :
Our studies reveal that recombinant
MIF induces cyclin D1 expression in a Rho-, Rho kinase-, MLC kinase-, and
ERK dependent manner in asynchronous NIH 3T3 fibroblasts
Lue et al., Cell Signal 2006
(MAP Kinase Signaling System) :
Applying the inhibitor genistein, a tyrosine kinase ( TPK ) activity was identified as a critical upstream signalling event in
MIF induced transient
ERK signalling ... A role for an upstream Src kinase was proven by applying Src-deficient cells which did not exhibit transient ERK activation upon treatment with MIF, but in which
MIF induced
ERK signalling could be restored by re-expressing Src ... Intriguingly, JAB1/CSN5, a signalosome component, cellular binding protein of MIF and regulator of cell proliferation and survival, had a marked, yet dual, effect on
MIF induced
ERK signalling ... By contrast, JAB1-knock-down by siRNA revealed that minimum JAB1 levels were necessary for transient
activation of
ERK by
MIF
Shi et al., Immunity 2006
:
CD74 alone mediated MIF binding ; however,
MIF induced
ERK1 and ERK2 kinase phosphorylation required the coexpression of full-length CD44 ... Investigations that used siRNA or kinase inhibitors indicate that
MIF induced
ERK1 and ERK2 activation through CD44 required the Src tyrosine kinase
Kim et al., Clin Exp Immunol 2008
(Scleroderma, Systemic) :
Furthermore,
MIF increased the expression of Bcl-2,
phospho-ERK and phospho-Akt activity in dermal fibroblasts
Kamir et al., J Immunol 2008
:
Like its mammalian counterpart,
Lm1740MIF induces
ERK1/2 MAP kinase activation in a CD74 dependent manner and inhibits the activation induced apoptosis of macrophages
Hare et al., Bioorg Med Chem Lett 2010
:
Additional studies for one of the potent inhibitors demonstrated that it is not a covalent inhibitor of MIF and that it attenuates
MIF dependent
ERK1/2 phosphorylation in human synovial fibroblasts
Jorgensen et al., Bioorg Med Chem Lett 2010
:
The agonist and antagonist behaviors were confirmed via study of
MIF dependent
ERK1/2 phosphorylation in human fibroblasts
Xie et al., PloS one 2011
(MAP Kinase Signaling System) :
In the current study, we described a detailed mechanism of
MIF mediated sustained
ERK activation
Jorgensen et al., Bioorg Med Chem Lett 2011
:
Consistently, both compounds were also found to retard the
MIF dependent phosphorylation of
ERK1/2 in human synovial fibroblasts
Zhang et al., Mediators Inflamm 2012
(Hypertension, Pulmonary) :
Besides, MIF antagonist ISO-1 suppressed the
ERK1/2 and JNK phosphorylation
induced by
MIF