◀ Back to EPHB2

EPHB2 — MAP2K2

Text-mined interactions from Literome

Majidi et al., J Biol Chem 2000 : Whereas wild-type p70 slightly inhibited ERK2 activation by RAS and MEK2 , co-expression or p70-DeltaC1 or p70-DeltaC2 with either protein stimulated ERK2 cooperatively
Meerzaman et al., Am J Physiol Lung Cell Mol Physiol 2001 : The activation of ERK2 was completely blocked either by a dominant negative Ras mutant or in the presence of a mitogen activated protein kinase kinase ( MEK ) inhibitor
Bobrovskaya et al., J Neurochem 2001 (MAP Kinase Signaling System) : The inhibitors of mitogen activated protein kinase kinase 1/2 ( MEK1/2 ) activation, PD98059 ( 0.1-50 microM ) and UO126 ( 0.1-10 microM ), dose-dependently inhibited both ERK2 and Ser31 phosphorylation on TOH in response to AII, suggesting MEK1/2 involvement
Wang et al., J Hepatol 2002 (MAP Kinase Signaling System) : PD 98059, a mitogen activated protein kinase kinase inhibitor, and glutathione, an anti-thiol-oxidant, not only blocked Cpd 5-induced ERK phosphorylation, but also antagonized the activation of CPP-32, the altered Bcl-2/Bax expression, and DNA fragmentation
Utsugi et al., Eur J Pharmacol 2002 : Furthermore, mitogen activated protein kinase kinase ( MEK)-1-specific inhibitor, 2- ( 2-amino-3-methoxyphenyl ) -4H-1-benzopyran-4-one ( PD 98059 ), blocked the lipopolysaccharide induced p44/42 ERK activation and PDGF production
Fahlman et al., Brain Res 2002 (Calcium Signaling...) : Increased phospho-ERK immunostaining was dependent on PLC and also on MEK 1/2 , an upstream regulator of ERK
Suthiphongchai et al., Oncol Res 2003 (Adenocarcinoma...) : Inhibition of mitogen activated protein kinase kinase 1 ( MEK1 ), an upstream regulator of ERK1/2 , with PD98059 resulted in a dose dependent reduction of invasiveness with different IC50 values in the three Dunning cell lines
Ohnishi et al., J Biol Chem 2004 : However, PD98059, a specific inhibitor of mitogen activated protein kinase kinase ( MEK1 ), inhibited ERK activation by TGF-beta(1), and consequently attenuated TGF-beta(1) enhancement of its own mRNA expression in PSCs
Song et al., J Leukoc Biol 2004 : Constitutively active mitogen activated protein kinase kinase ( MEK ) induced MIP-1alpha, and Ras dominant negative ( DN ) inhibited IC-induced ERK phosphorylation and MIP-1alpha production
Scholl et al., Cancer Res 2004 : Both Mek1 and Mek2 triggered ERK phosphorylation
Raines et al., Biochem J 2006 : Ca2+ mediated ERK1/2 activation in NO* producing cells could be restored by exogenous expression of constitutively active mitogen activated protein kinase kinase 1
Skarpen et al., FASEB J 2008 : Conversely, MEK2 activated ERK2 was retained in the cytoplasm and allowed survival
Chen et al., J Neurochem 2008 : Although mitogen activated protein kinase kinase ( MEK ) and extracellular signal regulated protein kinase ( ERK ) are activated by GW5074, pharmacological inhibition of MEK-ERK signaling by U0126 or PD98059 does not reduce neuroprotection suggesting that B-Raf signals through a non-canonical signaling pathway
Shama et al., Biochem Biophys Res Commun 2008 (Carcinoma...) : We used Tet-inducible shRNA to investigate the independent role of MEK1 and MEK2 for the oncogenic and the serum induced activation of ERK1 and ERK2 in LS174T colon carcinoma cells
Ko et al., Carcinogenesis 2008 (Carcinoma, Non-Small-Cell Lung...) : Enhancement of ERK1/2 signaling by constitutively active mitogen activated protein kinase kinase 1/2 ( MKK1/2-CA ) increased Rad51 protein levels and protein stability in gefitinib and cisplatin or MMC cotreated cells
Lorenz et al., Nat Med 2009 (Cardiomegaly...) : ERK1/2 is activated by mitogen activated protein kinase kinase-1 ( MEK1 ) and MEK2 ( commonly referred to as MEK1/2 ) -dependent phosphorylation in the TEY motif of the activation loop, but how ERK1/2 is targeted toward specific substrates is not well understood
Huang et al., Carcinogenesis 2009 (Glioma) : U-0126, the mitogen activated protein kinase kinase ( MAPK kinase ) inhibitors blocked ERK activation and cell proliferation induced by diazoxide
Catalanotti et al., Nature structural & molecular biology 2009 : Here we describe a previously uncharacterized, unexpected role of Mek1 in downregulating Mek2 dependent Erk signaling ... Thus, in disagreement with the current perception of the pathway, the role of Mek1 and Mek2 in growth factor induced Erk phosphorylation is not interchangeable
Petecchia et al., Chest 2009 (MAP Kinase Signaling System) : The involvement of epidermal growth factor receptor (EGFR)-extracellular signal regulated kinase ( ERK ) 1/2 cascade in CSC induced damage was shown by the observation that exposure to CSC ( 5 % ) induced a marked phosphorylation of ERK1/2, already detectable after 5-min incubation and confirmed by the demonstration that not only ERK1/2 phosphorylation but also CSC induced TJ disassembly and DNA fragmentation were partially inhibited by a mitogen activated protein kinase kinase inhibitor ( U0126 ) and completely blocked by a EGFR inhibitor ( AG1478 )
Pan et al., J Cell Sci 2010 : Active Mek2 as a regulatory scaffold that promotes Pin1 binding to BPGAP1 to suppress BPGAP1 induced acute Erk activation and cell migration
Luo et al., Oncogene 2011 : Ectopic expression of constitutively active mitogen activated protein kinase kinase 1 ( MKK1 ) resulted in activation of ERK1/2 and partially prevented CPX inhibition of LEC tube formation
Amatangelo et al., Carcinogenesis 2012 (Prostatic Neoplasms) : Mechanistic studies revealed that in cells stably transfected with activated Ras, TGF-ß alone induced EMT and that a Ras-Raf-MEK1, but not MEK2 , signaling cascade is necessary and sufficient for Erk2 nuclear localization that works in concert with TGF-ß to promote EMT
Yang et al., Genetics and molecular research : GMR 2012 (MAP Kinase Signaling System) : Constitutive activation of the mitogen activated protein kinase kinase 1 ( CaMEK ) can promote ERK1/2 expression, which is thereby expected to exert protective action on the heart against ischemia-reperfusion injury
Zheng et al., J Biol Chem 1993 : MEK2 is the most active ERK activator
Ludwig et al., J Biol Chem 1998 : ERK activation is strongly enhanced by overexpression of p38 and mitogen activated protein kinase kinase 6 ( MKK6 ) but is blocked by dominant negative kinase versions of p38 and MKK6 or the specific p38 inhibitor SB203580