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EPHB2 — FRS2

Text-mined interactions from Literome

Wu et al., Biol Chem 2003 : Notably, tyrosine phosphorylation of FRS2 is enhanced when ERK1/2 activation is inhibited after both EGF and FGF stimulation
Yamada et al., Biochem Biophys Res Commun 2004 (MAP Kinase Signaling System) : More Grb2-SOS complexes were recruited to the plasma membrane by binding to membrane bound FRS2 in FGF pathway than in EGF pathway and caused sustained activation of ERK
Mori et al., J Biol Chem 2008 : Nevertheless, R50E induced phosphorylation of FGFR1 and FRS2alpha and activation of AKT and ERK1/2
Haling et al., Mol Biol Cell 2010 (MAP Kinase Signaling System) : Thus, PEA-15 prevents ERK1/2 localization to the plasma membrane, thereby inhibiting ERK1/2 dependent threonine phosphorylation of FRS2alpha to promote activation of the ERK1/2 MAP kinase pathway
Sato et al., Stem Cells 2010 : FRS2a regulates Erk levels to control a self-renewal target Hes1 and proliferation of FGF-responsive neural stem/progenitor cells ... Quantitatively different levels of Erk activation mediated by FRS2a may regulate self-renewal of NSCs and proliferation of neural stem/progenitor cells ( NSPCs ) ; low levels of Erk activation are sufficient for the former, however, higher levels are required for maximum activity of the latter