Gene interactions and pathways from curated databases and text-mining

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EHMT1 — EPHB2

Text-mined interactions from Literome

Koehler et al., Mol Endocrinol 2005 : GLP-2 increased cAMP accumulation and activated ERK1/2 in HeLa cells transiently expressing the cloned human HeLa cell GLP-2R cDNA
Estall et al., J Biol Chem 2005 : The majority of the C-terminal receptor tail was dispensable for GLP-2 induced cAMP accumulation, ERK1/2 activation, and endocytosis in transfected cells
Syme et al., Mol Endocrinol 2006 : Finally, GLP-1R stimulated activation of ERK1/2 , which involves transactivation of epidermal growth factor receptors, required lipid raft integrity
Lagoumintzis et al., Scand J Immunol 2008 (Pseudomonas Infections) : Activation of both p38 and ERK1/2 induced by P. aeruginosa slime-GLP was dramatically reduced in the presence of anti-TLR2 and to a lesser degree in the presence of anti-TLR4, whereas the P. aeruginosa-LPS induced stimulation was inhibited only in the presence of anti-TLR4
Angelone et al., Nutr Metab Cardiovasc Dis 2012 (MAP Kinase Signaling System) : For the first time, to our knowledge, we found that : ( 1 ) the rat heart expresses functional GLP-2 receptors ; ( 2 ) GLP-2 acts on both myocardium and coronaries, negatively modulating both basal and ß-adrenergic stimulated cardiac performance ; and ( 3 ) GLP-2 effects are mediated by G-proteins and involve ERK1/2