◀ Back to EIF2AK3

EIF2AK3 — HSPA5

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: EIF2AK3 → Complex of EIF2AK3-HSPA5 (decreases, EIF2AK3/HSPA5 Activity)
  Evidence: Normally, the N-termini of these transmembrane ER proteins are held by ER chaperone Grp78 (BiP), preventing their aggregation. But when misfolded proteins accumulate, Grp78 releases, allowing aggregation of these transmembrane signaling proteins, and launching the UPR. Among the critical transmembrane ER signaling proteins are PERK, Ire1, and ATF6 (Figure 1) (reviewed in refs. 1, 2, # PERK = EIF2AK3
• Reactome Reaction: HSPA5 → EIF2AK3 (direct_complex)
• Reactome Reaction: HSPA5 → EIF2AK3 (reaction) Ma et al., J Biol Chem 2002*, Herbert et al., Biochem Soc Trans 2007*

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: HSPA5 — EIF2AK3 (physical association, affinity chromatography technology) Ma et al., J Biol Chem 2002*
• IRef Biogrid Interaction: HSPA5 — EIF2AK3 (physical association, affinity chromatography technology) Rao et al., Mol Cancer Ther 2010*
• IRef Hprd Interaction: HSPA5 — EIF2AK3 (in vivo) Ma et al., J Biol Chem 2002*
• IRef Intact Interaction: HSPA5 — EIF2AK3 (physical association, anti bait coimmunoprecipitation) Ma et al., J Biol Chem 2002*
• IRef Ophid Interaction: HSPA5 — EIF2AK3 (aggregation, confirmational text mining) Ma et al., J Biol Chem 2002*
• IRef Ophid Interaction: HSPA5 — EIF2AK3 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005