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CCL2 — TLR6
Text-mined interactions from Literome
Kurt-Jones et al., J Endotoxin Res 2004
:
MEFs were highly responsive to TLR-ligand activation and secreted high levels of both IL-6 and
MCP-1 in
response to
TLR ligands
Riccioli et al., J Immunol 2006
:
Moreover, we studied the role of NF-kappaB and of MAPKs in regulating
TLR mediated
MCP-1 secretion by using inhibitors specific for each transduction pathway and we demonstrated a pivotal role of the IkappaB/NF-kappaB and JNK systems
Yoshimura et al., J Immunol 2007
:
IFN-gamma mediated survival enables human neutrophils to produce
MCP-1/CCL2 in
response to activation by
TLR ligands
Lee et al., Cell Signal 2008
:
This study highlights the importance of cytosolic phospholipase A2 (cPLA2) mediated reactive oxygen species ( ROS ) signaling processes in the regulation of
MCP-1 release as a
result of
toll-like receptor ( TLR ) activation
Masamune et al., J Gastroenterol 2008
:
TLR ligands
induced expression of
monocyte chemoattractant protein 1 , cytokine induced neutrophil chemoattractant 1 ( a rat homolog of interleukin-8 ), and inducible nitric oxide synthase, but not proliferation or type I collagen production
Lee et al., Cell Microbiol 2009
:
In addition,
TLR2 , Dectin-1 and, to an extent, TLR4 are
essential for the MU-mediated expression of CXCL8,
CCL2 and LL-37 in keratinocytes
Jia et al., J Immunol 2009
(Listeriosis) :
The first phase is rapid, induces low-level production of
MCP-1 , and is
dependent on
TLR/MyD88 signaling
Dasu et al., Am J Physiol Endocrinol Metab 2011
(Diabetes Mellitus, Type 2...) :
Silencing TLR2,
TLR4 , and p47phox with small inhibitory RNAs ( siRNAs ) significantly
reduced superoxide release, NF-?B activity, IL-1ß, and
MCP-1 secretion in HG and palmitate treated THP-1 cells
Agarwal et al., Arthritis Res Ther 2011
(Fibrosis...) :
The ability of IFNa2 to regulate
TLR induced interleukin (IL)-6 and CC
chemokine ligand 2 production was also assessed
Tang et al., Contrib Nephrol 2011
(Diabetic Nephropathies...) :
In human DN biopsies and PTEC,
TLR4is upregulated and
plays a permissive role in HG-induced IL-6 and
CCL-2 overexpression and monocyte transmigration
Miura et al., Am J Physiol Gastrointest Liver Physiol 2012
(Fatty Liver...) :
Toll-like receptor (TLR)4 ( -/- ), TLR9 ( -/- ), and MyD88 ( -/- ) mice had reduced hepatic macrophage infiltration with decreased MCP-1 and CCR2 expression because
TLR signaling is a potent
inducer of
MCP-1
Salagianni et al., Circulation 2012
(Carotid Artery Diseases...) :
Mechanistically,
TLR7 interfered with macrophage proinflammatory responses to TLR2 and TLR4 ligands,
reduced monocyte chemoattractant protein-1 production, and prevented expansion of Ly6C ( hi ) inflammatory monocytes and accumulation of inflammatory M1 macrophages into developing atherosclerotic lesions