◀ Back to CASP7

CASP7 — TOP1

Text-mined interactions from Literome

Sordet et al., J Biol Chem 2004 (Leukemia) : The caspase inhibitor, benzyloxycarbonyl-VAD partially prevents arsenic trioxide induced topoisomerase I-DNA complexes and apoptosis, suggesting that activated caspases further maintain intracellular levels of reactive oxygen species that induce the formation of topoisomerase I-DNA complexes
Sheets et al., Infect Immun 2005 : Apoptosis associated events, including annexin V positivity, caspase-3 activation , and cleavage of the caspase substrates poly ( ADP-ribose ) polymerase and topoisomerase I (Topo I) , were observed in endothelial cells after detachment
Kelner et al., Invest New Drugs 2008 (Lung Neoplasms) : The synergistic interaction with these combinations may stem from a variety of actions including inhibition of the nucleotide excision repair ( NER ) pathway, topoisomerase I activity, and caspase dependent and independent induction of apoptosis
Sordet et al., J Biol Chem 2008 : Those apoptotic Top1cc are prevented by caspase inhibition and Bax inactivation, indicating that both caspases and the mitochondrial death pathway are required for their formation