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CASP6 — PIN1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Atabay et al., J Neurochem 2012
(Neurodegenerative Diseases) :
Here, we show that inhibition of
Pin1 by its selective inhibitor juglone
leads to up-regulation of cyclinD1, phospho-tau, and
caspase 3, producing apoptosis in cultured rat hippocampal neurons
Ghosh et al., J Biol Chem 2013
(Parkinson Disease...) :
Interestingly, multiple pharmacological
Pin1 inhibitors, including juglone,
attenuated MPP ( + ) -induced Pin1 up-regulation, a-synuclein aggregation,
caspase-3 activation, and cell death