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APAF1 — BCL2
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Hausmann et al., J Cell Biol 2000
:
However, neither
Bcl-2 nor Bcl-x ( L ) could
prevent the in vitro activation of
Apaf-1 induced by the addition of exogenous cytochrome c. Hence, rather than sequestering Apaf-1 as proposed by the apoptosome model, Bcl-2-like proteins probably regulate Apaf-1 indirectly by controlling upstream events critical for its activation
Mantena et al., Carcinogenesis 2006
(Lung Neoplasms...) :
Dietary GSPs ( 0.2 and 0.5 %, w/w ) significantly inhibited the growth of the implanted 4T1 tumor cells and increased the ratio of Bax :
Bcl-2 proteins, cytochrome c release,
induction of
Apaf-1 and activation of caspase 3 in the tumor microenvironment
Yu et al., Environ Toxicol 2012
(Carcinoma, Squamous Cell...) :
Safrole induced apoptosis was accompanied with up-regulation of the protein expression of Bax and Bid and down-regulation of the protein levels of
Bcl-2 ( up-regulation of the ratio of Bax/Bcl-2 ), resulting in cytochrome c release,
promoted Apaf-1 level and sequential activation of caspase-9 and caspase-3 in a time dependent manner
Hu et al., Proc Natl Acad Sci U S A 1998
:
Expression of
Bcl-XL inhibited the association of
Apaf-1 with caspase-9 in mammalian cells