◀ Back to WNT3
VDR — WNT3
Text-mined interactions from Literome
Cianferotti et al., Proc Natl Acad Sci U S A 2007
:
Thus, absence of the
VDR impairs canonical
Wnt signaling in keratinocytes and leads to the development of alopecia due to a defect in keratinocyte stem cells
Haussler et al., J Steroid Biochem Mol Biol 2010
:
VDR also
affects Wnt signaling through direct interaction with beta-catenin, ligand-dependently blunting beta-catenin mediated transcription in colon cancer cells to attenuate growth, while potentiating beta-catenin signaling via VDR ligand independent mechanisms in osteoblasts and keratinocytes to function osteogenically and as a pro-hair cycling receptor, respectively