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NPM1 — TP53

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: NPM1 — TP53 (physical association, affinity chromatography technology) Colombo et al., Nat Cell Biol 2002*
• IRef Biogrid Interaction: NPM1 — TP53 (physical association, affinity chromatography technology) Dhar et al., J Biol Chem 2006*
• IRef Biogrid Interaction: NPM1 — TP53 (physical association, affinity chromatography technology) Kurki et al., Cancer Cell 2004*
• IRef Biogrid Interaction: NPM1 — TP53 (direct interaction, pull down) Lambert et al., FEBS Lett 2006*
• IRef Biogrid Interaction: NPM1 — TP53 (direct interaction, pull down) Colombo et al., Nat Cell Biol 2002*
• IRef Hprd Interaction: TP53 — NPM1 (in vitro) Colombo et al., Nat Cell Biol 2002*, Lambert et al., FEBS Lett 2006*
• IRef Hprd Interaction: TP53 — NPM1 (in vivo) Colombo et al., Nat Cell Biol 2002*, Lambert et al., FEBS Lett 2006*
• IRef Intact Interaction: Complex of MDM2-TP53-NPM1-NPM1 (association, anti bait coimmunoprecipitation) Kurki et al., Cancer Cell 2004*
• IRef Intact Interaction: Complex of NPM1-NPM1-TP53 (association, anti bait coimmunoprecipitation) Kurki et al., Cancer Cell 2004*
• IRef Intact Interaction: Complex of TP53-MDM2-NPM1 (association, anti bait coimmunoprecipitation) Ji et al., EMBO Rep 2012*
• IRef Intact Interaction: NPM1 — TP53 (physical association, coimmunoprecipitation) Colombo et al., Nat Cell Biol 2002*
• IRef Intact Interaction: NPM1 — TP53 (physical association, anti bait coimmunoprecipitation) Kurki et al., Cancer Cell 2004*
• IRef Intact Interaction: NPM1 — TP53 (direct interaction, cross-linking study) Lambert et al., FEBS Lett 2006*
• IRef Intact Interaction: NPM1 — TP53 (direct interaction, surface plasmon resonance) Lambert et al., FEBS Lett 2006*

Text-mined interactions from Literome

Colombo et al., Nat Cell Biol 2002 (Neoplasms) : Nucleophosmin regulates the stability and transcriptional activity of p53 ... Here we show that NPM interacts directly with the tumour suppressor p53, regulates the increase in stability and transcriptional activation of p53 after different types of stress, and induces p53 dependent premature senescence on overexpression in diploid fibroblasts
Maiguel et al., Mol Cell Biol 2004 : NPM binds to the p53 N terminus and inhibits p53 transcriptional activity by more than 70 % ... Moreover, we show that NPM is a substrate for the UV-activated protein kinase ATR and inhibits the UV-induced p53 phosphorylation at Ser15
Kurki et al., Cancer Cell 2004 (Osteosarcoma) : Here we show that NPM is a UV damage response protein that undergoes nucleoplasmic redistribution and regulates p53 and HDM2 levels and their interaction
Li et al., J Biol Chem 2004 (Anoxia...) : Moreover, NPM inhibits hypoxia induced p53 phosphorylation at Ser-15 and interacts with p53 in hypoxic cells
Li et al., Leuk Res 2005 (Leukemia, Myeloid, Acute) : Negative regulation of p53 by nucleophosmin antagonizes stress induced apoptosis in human normal and malignant hematopoietic cells ... Moreover, NPM inhibits IR-induced p53 transactivation, and interacts with p53 in hematopoietic cells
Colombo et al., Mol Cell Biol 2005 (Fetal Death) : Lack of NPM expression results in accumulation of DNA damage, activation of p53 , widespread apoptosis, and mid-stage embryonic lethality
den Besten et al., Isr Med Assoc J 2006 (Leukemia, Myeloid) : A naturally occurring NPM mutant ( NPMc ) expressed in myeloid leukemia cells redirects both wild-type NPM and p19Arf to the cytoplasm, inhibits Arf induced sumoylation, and attenuates p53 activity
Li et al., Carcinogenesis 2007 (Genomic Instability) : Analysis of p53 stabilization and activation by c-Myc demonstrates that over-expression of NPM significantly reduces the accumulation of the activated p53 but not the stability of p53
Thompson et al., Apoptosis 2008 : Bcl-2 and p53 inhibited the interaction between full length activated Bax and nucleophosmin
Mascaux et al., Eur Respir J 2008 (Bronchial Neoplasms...) : Murine double minute clone 2 (MDM2), p14 alternate reading frame (p14arf), and nucleophosmin (NPM) regulate p53 activity
Jian et al., Oncogene 2009 (Neoplasms) : Importantly, NPM negatively regulates p53 and is frequently overexpressed in a wide variety of cancers
Chen et al., Int J Radiat Biol 2010 (Chromosomal Instability...) : Moreover, after irradiation, pThr1?? NPM levels increased significantly in WTK1 and TK6/p53i , and slightly increased in TK6 and TK6/NEGi, indicating that the increased level of pThr1?? NPM was related to p53 status
McDuff et al., PloS one 2011 (Cell Transformation, Neoplastic) : Furthermore, NPM-ALK attenuates p53 activity in an Rb and MDM2 dependent manner but this activity is not sufficient to bypass senescence
Marquez-Lona et al., Biochem Biophys Res Commun 2012 (Nerve Degeneration...) : In non-neuronal cell lines, NPM may enhance or inhibit the activity of tumor suppressor p53 , a major apoptotic protein
Li et al., Biomed Environ Sci 2011 (Lymphoma, Large-Cell, Anaplastic) : We also reveal a dynamic chain relation that NPM-ALK regulates p53 expression and subsequent apoptosis cascade in ALK+ ALCLs