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DMP1 — TP53
Text-mined interactions from Literome
Taneja et al., Cancer Res 2010
(Breast Neoplasms...) :
Critical
roles of
DMP1 in human epidermal growth factor receptor
2/neu-Arf-p53 signaling and breast cancer development ... Our study shows the pivotal
roles of
Dmp1 in
HER2/neu-p53 signaling and breast carcinogenesis
Frazier et al., Cancer Res 2012
:
Recent evidence suggests that
Dmp1 may
activate p53 independently of Arf in certain cell types ... Expression of
Dmp1 antagonized ubiquitination of p53 by Mdm2 and
promoted nuclear localization of
p53 ...
Dmp1-p53 binding significantly
increased the level of
p53 , independent of the DNA binding activity of Dmp1 ... Mechanistically,
p53 target genes were
activated synergistically by the coexpression of
Dmp1 and p53 in p53 ( -/- ) ; Arf ( -/- ) cells, and genotoxic responses of these genes were hampered more dramatically in Dmp1 ( -/- ) and p53 ( -/- ) cells than in Arf ( -/- ) cells ... Together, our findings identify a robust new mechanism of
p53 activation
mediated by direct physical interaction between
Dmp1 and p53