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IRAK3 — TLR4
Text-mined interactions from Literome
Kobayashi et al., Cell 2002
(Salmonella Infections) :
Thus,
IRAK-M regulates
TLR signaling and innate immune homeostasis ... Thus,
IRAK-M regulates
TLR signaling and innate immune homeostasis
Hazeki et al., Eur J Immunol 2003
:
PP2, an inhibitor of Src family tyrosine kinases, prevented the TLR induced phosphorylation of paxillin and Pyk2 without affecting
TLR induced
IRAK activation
Cuschieri et al., J Surg Res 2004
:
LPS stimulation led to the mobilization of
TLR4 to lipid rafts followed by phosphorylation and
activation of
IRAK , ERK 1/2, p38, and JNK/SAPK
Zhang et al., Infect Immun 2005
(Pseudomonas Infections) :
We also determined that MyD88,
IRAK , TRAF6, and Toll interacting protein (Tollip), but not TIRAP, were involved in the
TLR mediated response to P. aeruginosa in HAECs
Pathak et al., J Biol Chem 2005
:
Man-LAM exerts these effects by inducing the expression of
Irak-M , a negative
regulator of
TLR signaling
Seki et al., J Immunol 2010
(Acute Lung Injury...) :
We investigated the role of
IL-1 receptor associated kinase-M ( IRAK-M ), an
inhibitor of MyD88 dependent
TLR signaling, in modulating the innate inflammatory response during influenza pneumonia using a murine model
Turnis et al., J Immunol 2010
:
We found that
IRAK-M is
induced in DCs by
TLR ligation and that its absence from these cells leads to increased activation of the p38-MAPK and NF-?B pathways, which, in turn, improves DC migration to lymph nodes, increases their longevity, and augments their secretion of Th1 skewing cytokines and chemokines
Biswas et al., Eur J Immunol 2011
(Colitis...) :
Interestingly, the expression of
IRAK-M , a negative
regulator of
TLR signaling, is dependent on intestinal commensal flora, as IRAK-M expression was reduced in mice re-derived into a germ-free environment, and introduction of commensal bacteria into germ-free mice induced IRAK-M expression
Wu et al., J Allergy Clin Immunol 2012
(Asthma) :
IL-1 receptor associated kinase M ( IRAK-M ) negatively
regulates TLR signaling
Cole et al., Immunol Lett 2012
:
This study tested if murine bone marrow derived dendritic cells ( BM-DCs ) respond to endotoxin- and bacterial sonicate induced tolerance by decreased inflammatory and increased anti-inflammatory response, and the role of
IRAK-M , an intracellular negative
regulator of
TLR signaling, in this tolerance
Villena et al., Clinical and vaccine immunology : CVI 2012
:
Our results also indicated that TLR2 has an important role in the anti-inflammatory activity of L. jensenii TL2937, since anti-TLR2 antibodies blocked the upregulation of SIGIRR and
IRAK-M in CD172a ( + ) APCs and the production of IL-10 in
response to
TLR4 activation
Sandig et al., Eur J Immunol 2013
:
We show that while IRAK2 is redundant for TLR4 signaling,
IRAK1 is
essential for
TLR4 signaling in mast cells
Shiu et al., PloS one 2013
(Helicobacter Infections) :
IRAK-M , a negative
regulator of
TLR signaling, was upregulated and we selectedit for investigation of its role in modulating the DC and T cell responses
Sung et al., Biochem Biophys Res Commun 2013
:
Procyanidin dimer B2-mediated
IRAK-M induction negatively
regulates TLR4 signaling in macrophages ... Pro B2 markedly elevated the expression of the interleukin (IL)-1 receptor associated kinase (
IRAK)-M protein, a negative
regulator of
TLR signaling