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CFL2 — ROCK2

Text-mined interactions from Literome

Bongalon et al., J Vasc Res 2004 : Inhibition of ROCK ( Y-27632, 10 muM ) reduced only the IL-1beta stimulated LIMK2 and cofilin expression
Harenberg et al., Eur J Immunol 2005 : TXA ( 2 ) -induced apoptosis of double positive thymocytes and Rho activation required Lsc, and TXA ( 2 ) stimulation of actin polymerization and cofilin phosphorylation required both Lsc and Rho kinase ( ROCK )
Thirone et al., Am J Physiol Cell Physiol 2009 : Hyperosmolarity provoked cofilin phosphorylation was mediated by the Rho/Rho kinase ( ROCK ) /LIM kinase ( LIMK ) but not the Rac/PAK/LIMK pathway, because 1 ) dominant negative ( DN ) Rho and DN-ROCK but not DN-Rac and DN-PAK inhibited cofilin phosphorylation ; 2 ) constitutively active ( CA ) Rho and CA-ROCK but not CA-Rac and CA-PAK induced cofilin phosphorylation ; 3 ) hyperosmolarity induced LIMK-2 phosphorylation, and 4 ) inhibition of ROCK by Y-27632 suppressed the hypertonicity triggered LIMK-2 and cofilin phosphorylation.We thenexamined whether cofilin and its phosphorylation play a role in the hypertonicity triggered F-actin changes ... Taken together, cofilin is necessary for maintaining the osmotic responsiveness of the cytoskeleton in tubular cells, and the Rho/ROCK/LIMK mediated cofilin phosphorylation is a key mechanism in the hyperosmotic stress induced F-actin increase