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PLD2 — PXN
Text-mined interactions from Literome
Bae et al., Exp Mol Med 2001
:
In this study, we investigated the
role of
PLD on the ATP induced Fak activation and
paxillin phosphorylation using two established cell lines : wild type PLD2- and lipase-inactive mutant PLD2-inducible PC12 cells ... ATP also induced Fak activation, and
paxillin phosphorylation, and were dramatically
reduced by wild type
PLD2 overexpression but not by lipase-inactive mutant PLD2 overexpression ... We found that inhibition of tyrosine phosphatases by pervanadate completely blocked
PLD2 dependent Fak and
paxillin dephosphorylation ... Taken together, we suggest that
PLD2 activity might
play a negative role in ATP induced Fak and
paxillin phosphorylation possibly through tyrosine phosphatases
Pribic et al., Cell Signal 2012
:
Paxillin phosphorylation and complexing with Erk and FAK are
regulated by
PLD activity in MDA-MB-231 cells ... We investigated the
role of
PLD activity on
paxillin regulation, Erk activation and formation of a paxillin-Erk and paxillin-FAK association ... Inhibition of
PLD activity led to an increase in paxillin tyrosine phosphorylation, a decrease in Erk activation, as measured by phosphorylation, and
enhanced association of
paxillin with Erk ... Taken together, these results suggest that Erk activity is governed by
PLD activity and
regulates the tyrosine phosphorylation of
paxillin , potentially explaining its role in cell motility