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GDNF — PTK2
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Hisaoka et al., J Pharmacol Exp Ther 2007
:
Taken together, these findings indicate that ERK activation through
PTK regulates antidepressant induced
GDNF production and that the GDNF production in glial cells may be a novel action of the antidepressant, which is independent of monoamine
Hisaoka et al., Nihon Shinkei Seishin Yakurigaku Zasshi 2007
:
We reported that total
GDNF levels in whole blood in patients with mood disorders were significantly lower than those in healthy control subjects ( Takebayashi et al, 2006 ), and antidepressants
increased GDNF production through monoamine independent activation of
protein tyrosine kinase ( PTK ) and extracellular signal regulated kinase ( ERK ) in glial cells ( Hisaoka et al, 2007 )
Jing et al., Cell 1996
:
GDNF induced activation of the ret
protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF