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FGB — PTK2

Pathways - manually collected, often from reviews:

• Reactome Reaction: PTK2 → FGB (reaction) Schaller et al., Biochim Biophys Acta 2001, Giuliano et al., Biochem J 2003, Parsons et al., J Cell Sci 2003, Defilippi et al., Trends Cell Biol 2006, Mitra et al., Curr Opin Cell Biol 2006
• Reactome Reaction: PTK2 → FGB (indirect_complex) Schaller et al., Biochim Biophys Acta 2001, Mitra et al., Curr Opin Cell Biol 2006

Text-mined interactions from Literome

Kashiwagi et al., Blood 1999 : The binding of soluble fibrinogen to alphaIIbbeta3 ( T562N ) was not sufficient to trigger tyrosine phosphorylation of pp125(FAK) , indicating that additional post-ligand binding events are required to activate this protein tyrosine kinase during integrin signaling
Torti et al., Thromb Haemost 1999 : Concanavalin A-induced tyrosine phosphorylation of pp72syk, PLCgamma2 and pp125FAK was not dependent on platelet aggregation as it occurred normally even in the absence of sample stirring and when fibrinogen binding to integrin alphaIIb-beta3 was inhibited by the peptide RGDS
Hers et al., Arterioscler Thromb Vasc Biol 1998 : In the present study we measured the effect of the PTK inhibitor herbimycin A and the PKC inhibitor bisindolylmaleimide I on 125I-fibrinogen binding to alpha ( IIb ) beta3 and on aggregation/secretion induced by different agonists
Hato et al., J Cell Biol 1998 : However, clustering was sufficient to trigger fibrinogen independent tyrosine phosphorylation of pp72 ( Syk ) and fibrinogen dependent phosphorylation of pp125(FAK) , even in non-adherent cells