Gene interactions and pathways from curated databases and text-mining

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PLA2G4A — PRKCA

Pathways - manually collected, often from reviews:

  • KEGG Glutamatergic synapse: PRKCA/PRKCB/PRKCG → JMJD7-PLA2G4B/PLA2G10/PLA2G12A/PLA2G12B/PLA2G1B/PLA2G2A/PLA2G2C/PLA2G2D/PLA2G2E/PLA2G2F/PLA2G3/PLA2G4A/PLA2G4B/PLA2G4E/PLA2G5/PLA2G6 (protein-compound, activation)
  • KEGG Long-term depression: JMJD7-PLA2G4B/PLA2G10/PLA2G12A/PLA2G12B/PLA2G1B/PLA2G2A/PLA2G2C/PLA2G2D/PLA2G2E/PLA2G2F/PLA2G3/PLA2G4A/PLA2G4B/PLA2G4E/PLA2G5/PLA2G6 → PRKCA/PRKCB/PRKCG (protein-protein, compound)
  • KEGG Long-term depression: JMJD7-PLA2G4B/PLA2G10/PLA2G12A/PLA2G12B/PLA2G1B/PLA2G2A/PLA2G2C/PLA2G2D/PLA2G2E/PLA2G2F/PLA2G3/PLA2G4A/PLA2G4B/PLA2G4E/PLA2G5/PLA2G6 → PRKCA/PRKCB/PRKCG (protein-protein, compound)
  • KEGG GnRH signaling pathway: PRKCA/PRKCB/PRKCD → JMJD7-PLA2G4B/PLA2G10/PLA2G12A/PLA2G12B/PLA2G1B/PLA2G2A/PLA2G2C/PLA2G2D/PLA2G2E/PLA2G2F/PLA2G3/PLA2G4A/PLA2G4B/PLA2G4E/PLA2G5/PLA2G6 (protein-protein, indirect effect)

Text-mined interactions from Literome

Wang et al., Mol Pharmacol 2001 (Inflammation) : In summary, our results indicate that epidermal PKC alpha coordinately regulates cPLA(2) activity and COX-2 expression resulting in increased levels of AA and PGE ( 2 ) ... Furthermore, PKC alpha induced AA release and cPLA(2) phosphorylation are independent of MEK, whereas PKC alpha induced COX-2 expression and PGE ( 2 ) production are MEK dependent and C/EBP beta independent events
Awasthi et al., Am J Physiol Lung Cell Mol Physiol 2001 : We hypothesize that CT activity is inhibited by the lysoPC generated as a consequence of the activation of cPLA2 by protein kinase C-alpha and p38 mitogen activated protein kinase
Chakraborti et al., Biochemistry 2005 (Calcium Signaling) : We sought to determine the roles of PKCalpha and G ( i ) alpha in regulating cPLA(2) activity in bovine pulmonary artery endothelial cell membrane under peroxynitrite ( ONOO ( - ) ) stimulation
Anfuso et al., J Lipid Res 2007 (MAP Kinase Signaling System) : By confocal microscopy, activation of PKCalpha in perinuclear regions of ECs grown in coculture as well as strong activation of cPLA(2) in ECs taken from a model of mixed culture were clearly observed ... Our findings indicate that a sequential activation of PKCalpha contributes to endothelial ERK1/2 and cPLA(2) phosphorylation induced by either soluble factors or direct cell-to-cell contact, and that the PKCalpha-cPLA(2) pathway appears to play a key role in the early phase of EC-pericyte interactions regulating blood retina or blood-brain barrier maturation
Chang et al., J Immunol 1997 : Overexpression of PKC-alpha or -epsilon specifically inhibited receptor dependent cytosolic phospholipase A2 (cPLA2) activity, whereas this activity was enhanced in the PKC-betaI transfectant
Husain et al., Biochim Biophys Acta 1998 : The data presented are consistent with a role for PKCalpha , but not for p42/p44 mitogen activated protein kinase ( MAPK ), in cPLA2 activation and AA release in ET-1 stimulated CISM cells since : ( i ) the PKC inhibitor, RO 31-8220, inhibited ET-1 induced AA release, cPLA2 phosphorylation and cPLA2 activity, but had no inhibitory effect on p42/p44 MAPK activation, ( ii ) genistein, a tyrosine kinase inhibitor, inhibited ET-1 stimulated MAPK activity but had no inhibitory effect on AA release in the ET-1 stimulated cells