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PLA2G4A — PRKCA
Pathways - manually collected, often from reviews:
-
KEGG Glutamatergic synapse:
PRKCA/PRKCB/PRKCG
→
JMJD7-PLA2G4B/PLA2G10/PLA2G12A/PLA2G12B/PLA2G1B/PLA2G2A/PLA2G2C/PLA2G2D/PLA2G2E/PLA2G2F/PLA2G3/PLA2G4A/PLA2G4B/PLA2G4E/PLA2G5/PLA2G6
(protein-compound, activation)
-
KEGG Long-term depression:
JMJD7-PLA2G4B/PLA2G10/PLA2G12A/PLA2G12B/PLA2G1B/PLA2G2A/PLA2G2C/PLA2G2D/PLA2G2E/PLA2G2F/PLA2G3/PLA2G4A/PLA2G4B/PLA2G4E/PLA2G5/PLA2G6
→
PRKCA/PRKCB/PRKCG
(protein-protein, compound)
-
KEGG Long-term depression:
JMJD7-PLA2G4B/PLA2G10/PLA2G12A/PLA2G12B/PLA2G1B/PLA2G2A/PLA2G2C/PLA2G2D/PLA2G2E/PLA2G2F/PLA2G3/PLA2G4A/PLA2G4B/PLA2G4E/PLA2G5/PLA2G6
→
PRKCA/PRKCB/PRKCG
(protein-protein, compound)
-
KEGG GnRH signaling pathway:
PRKCA/PRKCB/PRKCD
→
JMJD7-PLA2G4B/PLA2G10/PLA2G12A/PLA2G12B/PLA2G1B/PLA2G2A/PLA2G2C/PLA2G2D/PLA2G2E/PLA2G2F/PLA2G3/PLA2G4A/PLA2G4B/PLA2G4E/PLA2G5/PLA2G6
(protein-protein, indirect effect)
Text-mined interactions from Literome
Wang et al., Mol Pharmacol 2001
(Inflammation) :
In summary, our results indicate that epidermal
PKC alpha coordinately
regulates cPLA(2) activity and COX-2 expression resulting in increased levels of AA and PGE ( 2 ) ... Furthermore,
PKC alpha induced AA release and
cPLA(2) phosphorylation are independent of MEK, whereas PKC alpha induced COX-2 expression and PGE ( 2 ) production are MEK dependent and C/EBP beta independent events
Awasthi et al., Am J Physiol Lung Cell Mol Physiol 2001
:
We hypothesize that CT activity is inhibited by the lysoPC generated as a consequence of the
activation of
cPLA2 by
protein kinase C-alpha and p38 mitogen activated protein kinase
Chakraborti et al., Biochemistry 2005
(Calcium Signaling) :
We sought to determine the
roles of
PKCalpha and G ( i ) alpha in regulating
cPLA(2) activity in bovine pulmonary artery endothelial cell membrane under peroxynitrite ( ONOO ( - ) ) stimulation
Anfuso et al., J Lipid Res 2007
(MAP Kinase Signaling System) :
By confocal microscopy, activation of
PKCalpha in perinuclear regions of ECs grown in coculture as well as strong
activation of
cPLA(2) in ECs taken from a model of mixed culture were clearly observed ... Our findings indicate that a sequential activation of
PKCalpha contributes to endothelial ERK1/2 and
cPLA(2) phosphorylation induced by either soluble factors or direct cell-to-cell contact, and that the PKCalpha-cPLA(2) pathway appears to play a key role in the early phase of EC-pericyte interactions regulating blood retina or blood-brain barrier maturation
Chang et al., J Immunol 1997
:
Overexpression of
PKC-alpha or -epsilon specifically
inhibited receptor dependent
cytosolic phospholipase A2 (cPLA2) activity, whereas this activity was enhanced in the PKC-betaI transfectant
Husain et al., Biochim Biophys Acta 1998
:
The data presented are consistent with a
role for
PKCalpha , but not for p42/p44 mitogen activated protein kinase ( MAPK ), in
cPLA2 activation and AA release in ET-1 stimulated CISM cells since : ( i ) the PKC inhibitor, RO 31-8220, inhibited ET-1 induced AA release, cPLA2 phosphorylation and cPLA2 activity, but had no inhibitory effect on p42/p44 MAPK activation, ( ii ) genistein, a tyrosine kinase inhibitor, inhibited ET-1 stimulated MAPK activity but had no inhibitory effect on AA release in the ET-1 stimulated cells