Gene interactions and pathways from curated databases and text-mining

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APP — PRKCA

Text-mined interactions from Literome

Jolly-Tornetta et al., Biochemistry 2000 : Regulation of amyloid precursor protein (APP) secretion by protein kinase calpha in human ntera 2 neurons ( NT2N )
Racchi et al., Mol Psychiatry 2003 (Neuroblastoma) : In this study, we characterized the role of PKCalpha in the regulated secretion of APP using wild-type SH-SY5Y neuroblastoma cells and cells transfected with a plasmid expressing PKCalpha antisense cDNA
Dehvari et al., J Neurochem 2007 (Alzheimer Disease) : Using APP knockout MEFs we showed that the expression of PKCalpha , but not the other PKC isoforms is partially dependent on APP and can be regulated by APP intracellular domain (AICD)
Slack et al., J Biol Chem 1993 : The results demonstrate that protein kinase C alpha regulates APP release in Swiss 3T3 fibroblasts, and perhaps in other tissues, including brain, and may be the isozyme that mediates receptor evoked release of APP