Tanaka et al., Proc Natl Acad Sci U S A 1999
(Diabetes Mellitus, Type 2) :
Addition of NAC or AG to the culture medium at least partially prevented decreases in insulin mRNA, insulin gene promoter activity, DNA binding of two important insulin promoter transcription factors ( PDX-1/STF-1 and RIPE-3b1 activator ), insulin content, and glucose induced insulin secretion
Fulghesu et al., Fertil Steril 2002
(Hyperinsulinism...) :
To evaluate the effect of N-acetyl-cysteine (NAC) on insulin secretion and peripheral insulin resistance in subjects with polycystic ovary syndrome ( PCOS )
Chen et al., Diabetes 2006
:
Antioxidant N-acetyl-l-cysteine (NAC) prevented mercury induced insulin secretion inhibition and Akt phosphorylation but not increased PI3K activity