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MMP14 — SPP1
Text-mined interactions from Literome
Philip et al., J Biol Chem 2001
(Melanoma...) :
Moreover, our data revealed that
OPN induced membrane type 1
(MT1) MMP expression correlates with translocation of p65 ( nuclear factor-kappaB (NF-kappaB) ) into the nucleus
Philip et al., J Biol Chem 2003
:
The
OPN induced pro-MMP-2 activation and
MT1-MMP expression were also drastically reduced by curcumin
Philip et al., Glycoconj J 2004
:
Curcumin blocks
OPN induced
MT1-MMP expression and pro-MMP-2 activation
Lai et al., Circ Res 2006
:
To better understand its role in vascular remodeling, we assessed how
OPN controls metalloproteinase (
MMP ) activation in aortic adventitial myofibroblasts ( AMFs ) and A7r5 vascular smooth muscle cells ( VSMCs )
Castellano et al., Clin Cancer Res 2008
(Disease Progression...) :
Osteopontin (OPN) , which
activates matrix metalloproteinases ( MMP ) , is considered a prognostic biomarker in several cancers ... `` In silico '' and experimental approaches were used to determine whether
OPN mediated
MMP activation may be a signal of prostate cancer progression
Buommino et al., Arch Dermatol Res 2012
(Psoriasis) :
Interestingly,
MMP-9 expression can be
enhanced also by
osteopontin (OPN) , a glycosylated protein whose levels are increased in skin and peripheral blood mononuclear cells ( PBMC ) of psoriasis patients
Tan et al., Lab Invest 2013
(Fibrosis...) :
Moreover,
MMP-9 inhibition
caused a significant reduction in MMP-9 cleaved
osteopontin and macrophage infiltration in UUO kidney