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LGALS1 — MAPK3
Text-mined interactions from Literome
Hsieh et al., Oncogene 2008
(Carcinoma, Squamous Cell...) :
The binding of
Gal-1 to NRP1 enhanced VEGFR-2 phosphorylation and
stimulated the activation of the
mitogen activated protein ( MAP ) kinases SAPK1/JNK ( stress activated protein kinase-1/c-Jun NH2-terminal kinase )
Shimizu et al., Lab Invest 2009
(Disease Models, Animal...) :
Moreover, recombinant
Gal-1 induced tyrosine phosphorylation of the cytoplasmic domain of nephrin and
activation of the
extracellular signal regulated kinase 1/2 in podocytes
Roda et al., Gastroenterology 2009
(Adenocarcinoma...) :
Down-regulation of Gal-1 by small interference RNA was used to analyze the
involvement of
Gal-1/tPA interaction in
extracellular signal regulated kinase 1/2 activation, cell proliferation, and invasion in pancreatic and fibroblastic cells
Brandt et al., Cell death & disease 2010
:
In this study we first show that
gal-1 initiates the activation of c-Jun N-terminal kinase (JNK),
mitogen activated protein kinase kinase 4 ( MKK4 ), and MKK7 as upstream JNK activators in Jurkat T cells