◀ Back to KRAS
KRAS — RAF1
Pathways - manually collected, often from reviews:
-
KEGG VEGF signaling pathway:
HRAS/KRAS/NRAS
→
RAF1
(protein-protein, activation)
-
KEGG Gap junction:
HRAS/KRAS/NRAS
→
RAF1
(protein-protein, activation)
-
KEGG Natural killer cell mediated cytotoxicity:
HRAS/KRAS/NRAS
→
ARAF/BRAF/RAF1
(protein-protein, activation)
-
KEGG T cell receptor signaling pathway:
HRAS/KRAS/NRAS
→
RAF1
(protein-protein, activation)
-
KEGG B cell receptor signaling pathway:
HRAS/KRAS/NRAS
→
RAF1
(protein-protein, activation)
-
KEGG Fc epsilon RI signaling pathway:
HRAS/KRAS/NRAS
→
RAF1
(protein-protein, activation)
-
KEGG Long-term potentiation:
HRAS/KRAS/NRAS
→
ARAF/BRAF/RAF1
(protein-protein, activation)
-
KEGG Neurotrophin signaling pathway:
HRAS/KRAS/NRAS
→
BRAF/RAF1
(protein-protein, activation)
-
KEGG Long-term depression:
HRAS/KRAS/NRAS
→
ARAF/BRAF/RAF1
(protein-protein, activation)
-
KEGG Regulation of actin cytoskeleton:
HRAS/KRAS/MRAS/NRAS/RRAS/RRAS2
→
ARAF/BRAF/MOS/RAF1
(protein-protein, activation)
-
KEGG Insulin signaling pathway:
HRAS/KRAS/NRAS
→
ARAF/BRAF/RAF1
(protein-protein, activation)
-
KEGG MAPK signaling pathway:
HRAS/KRAS/MRAS/NRAS/RRAS/RRAS2
→
RAF1
(protein-protein, activation)
-
KEGG GnRH signaling pathway:
HRAS/KRAS/NRAS
→
RAF1
(protein-protein, activation)
-
KEGG Progesterone-mediated oocyte maturation:
KRAS
→
ARAF/BRAF/RAF1
(protein-protein, activation)
-
KEGG Melanogenesis:
HRAS/KRAS/NRAS
→
RAF1
(protein-protein, activation)
-
KEGG Hepatitis C:
HRAS/KRAS/NRAS
→
ARAF/BRAF/RAF1
(protein-protein, activation)
-
KEGG Pathways in cancer:
HRAS/KRAS/NRAS
→
ARAF/BRAF/RAF1
(protein-protein, activation)
-
KEGG Colorectal cancer:
KRAS
→
ARAF/BRAF/RAF1
(protein-protein, activation)
-
KEGG Pancreatic cancer:
KRAS
→
ARAF/BRAF/RAF1
(protein-protein, activation)
-
KEGG Endometrial cancer:
HRAS/KRAS/NRAS
→
ARAF/BRAF/RAF1
(protein-protein, activation)
-
KEGG Endometrial cancer:
KRAS
→
ARAF/BRAF/RAF1
(protein-protein, activation)
-
KEGG Glioma:
HRAS/KRAS/NRAS
→
ARAF/BRAF/RAF1
(protein-protein, activation)
-
KEGG Glioma:
HRAS/KRAS/NRAS
→
ARAF/BRAF/RAF1
(protein-protein, activation)
-
KEGG Prostate cancer:
HRAS/KRAS/NRAS
→
ARAF/BRAF/RAF1
(protein-protein, activation)
-
KEGG Melanoma:
HRAS/KRAS/NRAS
→
ARAF/BRAF/RAF1
(protein-protein, activation)
-
KEGG Bladder cancer:
HRAS/KRAS/NRAS
→
ARAF/BRAF/RAF1
(protein-protein, activation)
-
KEGG Chronic myeloid leukemia:
HRAS/KRAS/NRAS
→
ARAF/BRAF/RAF1
(protein-protein, activation)
-
KEGG Acute myeloid leukemia:
HRAS/KRAS/NRAS
→
ARAF/BRAF/RAF1
(protein-protein, activation)
-
KEGG Acute myeloid leukemia:
KRAS
→
ARAF/BRAF/RAF1
(protein-protein, activation)
-
KEGG Non-small cell lung cancer:
KRAS
→
ARAF/BRAF/RAF1
(protein-protein, activation)
-
KEGG Non-small cell lung cancer:
HRAS/KRAS/NRAS
→
ARAF/BRAF/RAF1
(protein-protein, activation)
-
KEGG ErbB signaling pathway:
HRAS/KRAS/NRAS
→
ARAF/BRAF/RAF1
(protein-protein, activation)
-
KEGG Chemokine signaling pathway:
HRAS/KRAS/NRAS
→
BRAF/RAF1
(protein-protein, activation)
-
NCI Pathway Database PDGFR-beta signaling pathway:
RAF1/14-3-3 (dimer) complex (RAF1-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB)
→
RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS)
(modification, collaborate)
Mason et al., EMBO J 1999, Ory et al., Curr Biol 2003, McKay et al., Proc Natl Acad Sci U S A 2009, Dhillon et al., Cell Signal 2009, Ritt et al., Mol Cell Biol 2010, Michaud et al., Mol Cell Biol 1995, Muslin et al., Cell 1996
Evidence: assay, physical interaction
-
Reactome Reaction:
RAF1
→
KRAS
(indirect_complex)
Morrison et al., Curr Opin Cell Biol 1997*
-
Reactome Reaction:
RAF1
→
KRAS
(reaction)
Morrison et al., Curr Opin Cell Biol 1997*
-
WikiPathways Extracellular vesicle-mediated signaling in recipient cells:
HRAS/KRAS
→
RAF1
(activation)
-
WikiPathways Focal Adhesion-PI3K-Akt-mTOR-signaling pathway:
NRAS/KRAS/HRAS
→
RAF1
(activation)
-
WikiPathways MAPK Cascade:
HRAS/NRAS/RRAS/KRAS
→
RAF1/ARAF/BRAF
(activation)
-
WikiPathways MAPK Signaling Pathway:
MRAS/NRAS/KRAS
→
BRAF/RAF1/MOS
(activation)
-
WikiPathways Serotonin Receptor 2 and ELK-SRF/GATA4 signaling:
HRAS/KRAS/NRAS
→
RAF1
(mim-necessary-stimulation)
-
WikiPathways Signaling Pathways in Glioblastoma:
NRAS/KRAS/HRAS
→
ARAF/BRAF/RAF1
(mim-stimulation)
-
WikiPathways Aryl Hydrocarbon Receptor:
NRAS/HRAS/KRAS
→
RAF1
(mim-conversion)
-
WikiPathways Chemokine signaling pathway:
HRAS/KRAS/NRAS
→
BRAF/RAF1
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
RAF1
—
KRAS
(direct interaction, pull down)
Sui et al., Oncogene 2009*
-
IRef Biogrid Interaction:
RAF1
—
KRAS
(physical association, affinity chromatography technology)
Lito et al., Cancer Cell 2012*
-
IRef Biogrid Interaction:
RAF1
—
KRAS
(physical association, affinity chromatography technology)
Rajalingam et al., Nat Cell Biol 2005
-
IRef Biogrid Interaction:
RAF1
—
KRAS
(physical association, affinity chromatography technology)
Zhu et al., Mol Biol Cell 2005
-
IRef Biogrid Interaction:
RAF1
—
KRAS
(physical association, affinity chromatography technology)
Blaukat et al., Mol Cell Biol 2000*
-
IRef Biogrid Interaction:
RAF1
—
KRAS
(direct interaction, two hybrid)
Li et al., Genes Dev 2000
-
IRef Biogrid Interaction:
RAF1
—
KRAS
(physical association, affinity chromatography technology)
Kiyono et al., J Biol Chem 2000*
-
MIPS CORUM RAF1-RAS complex, EGF induced:
RAF1-RAS complex, EGF induced complex (RAF1-HRAS-KRAS-NRAS)
Garnett et al., Mol Cell 2005
-
IRef Corum Interaction:
Complex of RAF1-KRAS-HRAS-NRAS
(association, anti bait coimmunoprecipitation)
Garnett et al., Mol Cell 2005
-
IRef Dip Interaction:
RAF1
—
KRAS
(direct interaction, fluorescent resonance energy transfer)
Abankwa et al., Proc Natl Acad Sci U S A 2010*
-
IRef Hprd Interaction:
RAF1
—
KRAS
(in vitro)
Sakatsume et al., J Biol Chem 1998*
-
IRef Intact Interaction:
RAF1
—
KRAS
(direct interaction, pull down)
Alvarez-Moya et al., Oncogene 2010*
-
IRef Intact Interaction:
RAF1
—
KRAS
(physical association, anti tag coimmunoprecipitation)
Alvarez-Moya et al., Oncogene 2010*
-
IRef Ophid Interaction:
RAF1
—
KRAS
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Roy et al., Mol Cell Biol 2002
:
Inhibition of endocytosis by dominant interfering dynamin-K44A blocked H-Ras but not K-Ras mediated PC12 cell differentiation and selectively inhibited H-Ras- but not
K-Ras mediated
Raf-1 activation in BHK cells ... H-Ras- but not
K-Ras mediated
Raf-1 activation was also selectively dependent on phosphoinositide 3-kinase activity
Moretó et al., Cell Signal 2009
(MAP Kinase Signaling System) :
Differential
involvement of H- and
K-Ras in
Raf-1 activation determines the role of calmodulin in MAPK signaling ... In the present study, we show that CaM has completely opposite effects on
K-Ras mediated
Raf-1 activation
Hoogwater et al., Gastroenterology 2010
(Colorectal Neoplasms...) :
Oncogenic K-Ras and its effector
Raf1 convert death receptors into invasion inducing receptors by suppressing the ROCK/LIM kinase pathway, and this is
essential for
K-Ras/Raf1-driven metastasis formation
Yan et al., J Biol Chem 1998
:
Thus,
Ki-Ras both recruits Raf-1 to the plasma membrane more efficiently than Ha-Ras and is a more potent
activator of membrane recruited
Raf-1 than Ha-Ras