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ICOS — IL2

Text-mined interactions from Literome

Coyle et al., Immunity 2000 : We suggest that ICOS , the third member of the CD28/CTLA-4 family, plays an important role in production of IL-2 , IL-4, IL-5, and IFNgamma from recently activated T cells and contributes to T cell dependent B help in vivo
Gonzalo et al., J Immunol 2001 : Our data suggest that ICOS and CD28 regulate T cell expansion and that ligation of either CD28 or ICOS can either uniquely regulate cytokine production ( IL-2/TNF-alpha ) or synergize for optimal cytokine production ( IL-4 ) after SAg administration
Riley et al., J Immunol 2001 : ICOS costimulation requires IL-2 and can be prevented by CTLA-4 engagement
Sporici et al., Clin Immunol 2001 (Encephalomyelitis, Autoimmune, Experimental) : ICOS-Ig did not prevent IL2 production, demonstrating that IL-2 production is ICOS ligand independent
Wahl et al., J Am Soc Nephrol 2002 : Interestingly, interleukin-2 production by T cell hybridomas after antigen presentation by TEC was enhanced by blocking antibodies to B7RP-1 and ICOS ... Interestingly, interleukin-2 production by T cell hybridomas after antigen presentation by TEC was enhanced by blocking antibodies to B7RP-1 and ICOS
Harada et al., J Exp Med 2003 : A single amino acid alteration in cytoplasmic domain determines IL-2 promoter activation by ligation of CD28 but not inducible costimulator (ICOS)
Mesturini et al., Eur J Immunol 2006 : ICOS strikingly potentiated secretion of IL-2 , IFN-gamma, IL-10, and TNF-alpha, but not IL-4, promoted by optimal stimulation of CD3+CD28, and it was the key switching-factor of activation when cells received suboptimal stimulation of CD3+CD28 or stimulation of CD3 alone in the presence of exogenous IL-2
Nagamatsu et al., Immunol Cell Biol 2011 : ICOS ligation enhanced T-cell secretion of interferon-gamma ( IFN-? ) and interleukin-10 (IL-10), but not IL-2