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CISH — IL2

Pathways - manually collected, often from reviews:

• NCI Pathway Database IL2-mediated signaling events: IL2 (IL2) → IL2R beta/JAK1/LCK/CISH complex (IL2RB-JAK1-LCK-CISH) (modification, collaborate)
  Delespine-Carmagnat et al., FEBS Lett 1999, Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Arima et al., J Immunol 1991, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Sharon et al., Science 1986, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Miyazaki et al., Science 1994, Beadling et al., EMBO J 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Endo et al., Nature 1997, Liu et al., Curr Biol 1997, Zhou et al., Proc Natl Acad Sci U S A 1997, Fujii et al., EMBO J 1998
  Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species

Text-mined interactions from Literome

Okabe et al., Exp Hematol 1999 : CIS1 is induced by interleukin-2 (IL-2) , IL-3, GM-CSF, and erythropoietin (EPO), but not by IL-6, granulocyte colony stimulating factor ( G-CSF ), or stem cell factor
Frobøse et al., Mol Endocrinol 2006 : Suppressor of cytokine Signaling-3 inhibits interleukin-1 signaling by targeting the TRAF-6/TAK1 complex
Dawson et al., BMC immunology 2006 : Stimulation of human PBMCs and purified T cells with ATRA and 9-cis-RA increased mRNA and protein levels of IL-4, IL-5, and IL-13 and decreased levels of IFN-gamma, IL-2 , IL-12p70 and TNF-alpha upon activation with anti-CD3 and/or anti-CD28 mAbs
Zhang et al., Vaccine 2008 (Foot-and-Mouth Disease) : The results showed that higher specific antibody, proliferate rate and cytokines were induced by plasmid DNA cis-expression with IL-2 compared to non-cis-expression plasmid DNA
Choi et al., J Biol Chem 2010 : Moreover, SOCS-6 overexpression led to repression of TCR dependent interleukin-2 promoter activity
Matsumoto et al., Blood 1997 : The mutant IL-2 receptor that fails to activate STAT5 could not induce CIS , suggesting that STAT5 is involved in the cytokine-inducible expression of CIS
Quinn et al., Hum Gene Ther 1998 : In this study, retrovirus mediated gene transfer and the fate of proviral gene expression were evaluated in human T cells activated using ( 1 ) immobilized anti-CD3 monoclonal antibody ( MAb ) plus interleukin 2 , or ( 2 ) cis costimulation using beads carrying coimmobilized anti-CD3 and anti-CD28 MAbs
Powell et al., Immunol Rev 1998 : Furthermore, T-cell anergy appears to be an active negative state in which IL-2 production is inhibited both at the level of signal transduction and by cis-dominant repression at the level of the IL-2 promoter