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CD86 — IL2

Text-mined interactions from Literome

Blazevic et al., J Clin Immunol 2001 : Inhibition studies using the B7-binding fusion protein CTLA4Ig and antibodies against CD80 and CD86 demonstrate that CTLA4Ig and anti-CD86 inhibited influenza-specific T cell proliferation, interleukin (IL)-2 and interferon (IFN)-gamma production, and generation of influenza-specific CD8+ CTL
Rückert et al., J Invest Dermatol 2002 (Dermatitis, Contact) : IL-2-IgG2b but not IL-15-IgG2b fusion protein reduced migration of antigen presenting cells from the skin to local lymph nodes, inhibited the expression of CD80 and CD86 , and induced a significant higher number of CD4+CD25+ T cells
Sindhi et al., J Immunol Methods 2003 : PD analyses suggested that in NHS samples containing CsA+SRL ( n=5 ), ( 1 ) PMA-Ionomycin stimulated T-cell expression of intracellular IL-2 , TNF-alpha, and IFN-gamma was inhibited by CsA, and minimally by SRL, and ( 2 ) the two agents inhibited pokeweed mitogen ( PWM ) -stimulated B-cell expression of CD54 and CD95, but not CD86 ( ICAM-1, Fas antigen, and B7.2 ), synergistically
Spaner et al., Br J Haematol 2004 (Leukemia, Lymphocytic, Chronic, B-Cell) : CD80 and CD86 induction by IL-2 were positively regulated through the mitogen activated protein kinase pathway, while CD86 expression was negatively regulated through Janus kinase pathways
Olsson et al., Int Immunol 1998 : However, IL-2 production reached only suboptimal levels in the presence of CD86 but optimal levels with CD80